Tuberculosis and Fungal Co-infection of Fungal Infections, University Hospital Center Zagreb, Croatia, During Past Two Years

Tuberculosis and Fungal Co-infection of Fungal Infections, University Hospital Center Zagreb, Croatia, During Past Two YearsConference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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We examined the relationship between the metabolic processes of carbon catabolite repression (CCR), nitrogen catabolite repression (NCR) and virulence in a variety of A. fumigatus clinical isolates. A considerable amount of heterogeneity with respect to the degree of CCR and NCR was observed and a positive correlation between NCR and virulence in a neutropenic mouse model of pulmonary aspergillosis (PA) was found. Isolate Afs35 was selected for further analysis and compared to the reference strain A1163, with both strains presenting the same degree of virulence in a neutropenic mouse model of PA. Afs35 metabolome analysis ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study they also showed PTX3 localized in NETs formed after neutrophil activation (5). Proteomics analysis revealed that PTX3 forms complexes with two anti-microbial proteins [azurocidin (AZU1) and myeloperoxidase (MPO)] associated to NETs (30). More recently, PTX3 localization in NETs has been confirmed, and the colocalization with AZU1 and MPO has been defined more accurately (31). Further investigation will be needed to understand the involvement of PTX3 interaction with AZU1 and MPO in their antibacterial role during NET formation. Regulation of Complement Activation PTX3 interaction with microorganisms is not...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
This article is protected by copyright. All rights reserved. Fungal infections that result in the death of immunocompromised subjects have risen steadily over the last few years. The metabolic utilisation of preferred carbon and nitrogen sources, encountered in a host niche‐specific manner, has been shown to be an important virulence determinant. Characterisation of preferred nutrient source utilisation, including sensing and uptake, by pathogenic fungi has only been partially characterised, and further species‐specific elucidation is required, in order to uncover targets for anti‐fungal therapies.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Microreview Source Type: research
Rationale: The simultaneous occurrence of pyoderma gangrenosum (PG) and chronic granulomatous disease (CGD) is uncommon and few cases have been reported worldwide. Patient concerns: PG is a rare, chronic, ulcerative, neutrophilic skin disease of unknown etiology that requires immunosuppressive treatment. CGD belongs to Primary Immune Deficiencies in which the main defect lies in an inability of the phagocytic cells to generate superoxide making patients susceptible to serious, potentially life-threatening bacterial and fungal infections. Diagnoses: In this manuscript, we present a case of ulcerative pyoderma gangrenosum ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusions:The current clinical observation serves to remind clinicians of the challenges faced in diagnosing brain ring-enhancing lesions, especially in patients with pre-existing brain disorders. Furthermore, it highlights the difficulty in treating invasive fungal infections in immunocompromised hosts. More studies are needed to establish the incidence and clinical course of invasive fungal infections in patients with sarcoidosis and infliximab therapy.Disclosure: Dr. Van Sanford has nothing to disclose. Dr. Obeidat has nothing to disclose. Dr. Zabeti has received personal compensation for activities with Biogen, Genzy...
Source: Neurology - Category: Neurology Authors: Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research
Chronic pulmonary aspergillosis (CPA) is a severe fungal infection usually seen in immunocompetent patients with underlying respiratory disorders [1]. Estimates suggest that ~3 million people suffer from CPA globally [2]. The precise prevalence is unknown. Pulmonary tuberculosis (TB) seems to be the most relevant driver for the global burden of CPA with estimates suggesting about 1.2 million patients with CPA as a sequel to TB [3]. Given that there were 10.4 million new TB cases in 2015, CPA represents a serious sequela to pulmonary TB [4]. However, any search for CPA in the Global Tuberculosis Report of the World Hea...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections and tuberculosis Editorials Source Type: research
Publication date: July 2016 Source:Journal of Molecular Graphics and Modelling, Volume 68 Author(s): Warot Chotpatiwetchkul, Nathjanan Jongkon, Supa Hannongbua, M. Paul Gleeson Aspergillus niger is an industrially important microorganism used in the production of citric acid. It is a common cause of food spoilage and represents a health issue for patients with compromised immune systems. Recent studies on Aspergillus niger have revealed details on the isocitrate lyase (ICL) superfamily and its role in catabolism, including (2R, 3S)-dimethylmalate lyase (DMML). Members of this and related lyase super families are of c...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
CONCLUSION: This report describes the course of the patient's illness in order to highlight the challenges associated with the management of these infections. We also aim to stress on the importance of pathological diagnosis before starting a therapy. PMID: 27308089 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
CONCLUSIONS: A. fumigatus and C. albicans were the most common etiological agents of fungal respiratory pathogens associated with CF patients. A. fumigatus strains were in vitro 100% susceptible to azole and amphotericin B. Two strains of C. albicans and one strain of C. tropicalis were non-susceptible to azole (fluconazole, itraconazole and voriconazole). Scedosporium apiospermum was resistant to amphotericin B (MIC> 32 mg/l) and susceptible to voriconazole (MIC 0.094 mg/l). PMID: 27238177 [PubMed - in process]
Source: Pneumonologia i Alergologia Polska - Category: Respiratory Medicine Authors: Tags: Pneumonol Alergol Pol Source Type: research
Publication date: Available online 26 May 2016 Source:Journal of Molecular Graphics and Modelling Author(s): Warot Chotpatiwetchkul, Nathjanan Jongkon, Supa Hannongbua, M. Paul Gleeson Aspergillus niger is an industrially important microorganism used in the production of citric acid. It is a common cause of food spoilage and represents a health issue for patients with compromised immune systems. Recent studies on Aspergillus niger have revealed details on the isocitrate lyase (ICL) superfamily and its role in catabolism, including (2R, 3S)-dimethylmalate lyase (DMML). Members of this and related lyase super families ...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
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