Modulation of Gut Microbiota through Dietary Phytochemicals as a Novel Anti-infective Strategy.

Modulation of Gut Microbiota through Dietary Phytochemicals as a Novel Anti-infective Strategy. Curr Drug Discov Technol. 2019 Nov 07;: Authors: Mujawdiya PK, Kapur S Abstract Quorum sensing (QS) is a phenomenon in which bacterial cells communicate with each other with the help of several low molecular weight compounds. QS is largely dependent on population density, and it triggers when the concentration of quorum sensing molecules accumulate in the environment and crosses a particular threshold Once a certain population density is achieved and the concentration of molecules cross a threshold the bacterial cells show a collective behavior in response to various chemical stimuli referred to as "auto-inducers". The QS signaling is crucial for several phenotypic characteristics responsible for bacterial survival such as motility, virulence, and biofilm formation. Biofilm formation is also responsible for making bacterial cells resistant to antibiotics. The human gut is home to trillions of bacterial cells collectively called "gut microbiota" or "gut microbes". Gut microbes are a consortium of more than 15,000 bacterial species and playa very crucial role in several body functions such as metabolism, development and maturation of immune system, and the synthesis of several essential vitamins. Due to its critical role in shaping the human survival and its modulating impact on body metabolisms, the gut microbial community has been referred...
Source: Current Drug Discovery Technologies - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Discov Technol Source Type: research