Resveratrol suppresses nociceptive jaw-opening reflex via 5HT3 receptor-mediated GABAergic inhibition 

Publication date: Available online 9 November 2019Source: Neuroscience ResearchAuthor(s): Kounosuke Hirata, Yuto Nishiki, Ryosuke Goto, Mikito Inagaki, Katsuo Oshima, Yoshihito Shimazu, Mamoru TakedaAbstractSystemic administration of the dietary constituent, resveratrol, was previously shown to inhibit the nociceptive jaw-opening reflex (JOR) via the endogenous opioid system. The present study investigated whether resveratrol could similarly affect the JOR under in vivo conditions via 5 H T3 receptor-mediated GABAergic inhibition. We used electrical stimulation of the tongue in pentobarbital-anesthetized rats to evoke the JOR, which was recorded as the anterior belly of the digastric muscle electromyograms (dEMG). Intravenous administration of resveratrol (2 mg/kg) reduced the dEMG amplitude in response to three times the determined threshold electrical stimulation, with maximum inhibition reached within approximately 10 min. These inhibitory effects on the JOR were reversible to control levels after approximately 20 min. Pretreatment of rats with either 5 H T3 receptor antagonist, ondansetron (0.25-1 mg/kg, i.p.), or GABAA receptor antagonist, bicuculline (0.5-1 mg/kg, i.p.), significantly and dose-dependently attenuated the inhibitory effects of resveratrol on dEMG amplitude compared with untreated controls. These findings suggest that resveratrol also attenuates the nociceptive JOR via 5 H T3 rece...
Source: Neuroscience Research - Category: Neuroscience Source Type: research

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CONCLUSION: This study showed that calcitonin could be helpful analgesic agent in different painful situations. Calcitonin can be considered an eligible treatment for acute pains related to vertebral fractures and a feasible alternative for the treatment of the acute and chronic neuropathic pains where other medications might fail. PMID: 31810524 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Anestesiologia - Category: Anesthesiology Tags: Rev Bras Anestesiol Source Type: research
Millions of people with post-traumatic stress disorder (PTSD) — from veterans to rape survivors — have new hope because of a watershed study showing that the injection of an anesthetic to a bundle of nerves in the neck can relieve their symptoms in a clinically significant way. The treatment is known as the stellate ganglion block, or SGB. Used since 1925 for problems such as pain in the arm and shingles, it is safe and effective. In the newly released, eight-week, U.S. Army-funded clinical trial of 108 active-duty service members with PTSD, the nonprofit research institute RTI International found that patients...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Personal PTSD Research Treatment Hyper Vigilance Neuroscience Neurotransmitter Norepinephrine Posttraumatic Stress Disorder pruning Source Type: blogs
Publication date: Available online 6 December 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): Klaus Weber, Rüdiger Häcker, Jerold F. Hardisty, Stephen B. Harris, A. Wallace HayesAbstractBIA 10–2474 (3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide) is a novel fatty acid amide hydrolase (FAAH) inhibitor developed by BIAL for the treatment of medical conditions which would benefit from enhanced levels of endogenous anandamide (AEA) such as pain disorders. During a Phase I clinical trial one subject died after receiving BIA 10–2474 and others displayed neurological signs....
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
AbstractThe innervation of the long head of the biceps tendon (LHBT) is not sufficiently documented. This is a drawback since pathologies of the LHBT are a major source of shoulder pain. Thus, the study aimed to characterize structurally and molecularly nervous elements of the LHBT. The proximal part of 11 LHBTs was harvested intraoperatively. There were 8 female and 3 male specimens. Age ranged from 66 to 86  years. For structural analyses, nervous elements were viewed in the transmission electron microscope. For molecular characterization, we used general neuronal markers including antibodies against neurofilament a...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
ConclusionDecreases in O2 saturation and heart rate may be regarded as physiological effects of TNFFL. No significant difference between two routes was noted in the present study in terms of physiological effects and patient comfort during TNFFL. Introducing the endoscope between the inferior and middle turbinates may be a comfortable and safe option, particularly if the endoscope cannot be advanced along the nasal floor due to septum deviation, septal crest, inferior turbinate hypertrophy.
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
Conclusion: Functional diarrhea was associated with hemodynamic indices of sympathetic activation, supporting a possible role of the autonomic nervous system in diarrhea. PMID: 31791149 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
___ Life throws chaos at us on a regular basis—whether it’s our finances, our relationships, or our health. In the work world, around 50 percent of people are burned out in industries like health care, banking, and nonprofits, and employers spend $300 billion per year on workplace-related stress. In response, we just keep on pushing through, surviving on adrenaline. We overschedule ourselves; we drink another coffee; we respond to one more email. If we stay amped up all the time, we think, we’ll eventually be able to get things done. But all that does is burn us out, drain our productivity, and lead to ex...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness adrenaline Breathing coffee creativity Decision-making exhaustion Mindfulness-Training productivity relaxed state-of-mind Stress Stress Response workplace Source Type: blogs
This study aimed to analyze the clinical safety and effectiveness of endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN) in alleviating intractable abdominal pain caused by advanced pancreatic cancer. A total of 58 patients with inoperable pancreatic cancer who underwent EUS-CPN from May 2015 to December 2017 were enrolled. Pain levels before and after EUS-CPN were assessed and compared using the Visual Analogue Scale. The preoperative Visual Analogue Scale score was 8.2±2.3, which decreased significantly to 3.6±1.5 at 2 days after EUS-CPN and to 2.2±0.8 after 1 month. The response rate was...
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - Category: Surgery Tags: Original Articles Source Type: research
Publication date: Available online 28 November 2019Source: Pharmacological ResearchAuthor(s): Alexandre Kanashiro, Carlos Hiroji Hiroki, Denise Morais da Fonseca, Alexander Birbrair, Raphael Gomes Ferreira, Gabriel Shimizu Bassi, Mirian D. Fonseca, Ricardo Kusuda, Guilherme Cebinelli, Katiussia Pinho da Silva, Carlos Wagner Wanderley, Gustavo Batista Menezes, José Carlos Alves Filho, André Gustavo Oliveira, Thiago M. Cunha, André Pupo, Luis Ulloa, Fernando Q. CunhaAbstractNeutrophils are peripheral immune cells that represent the first recruited innate immune defense against infections and tissue injur...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: It is important for dermatologists and otolaryngologists to be aware that symptomatic mucosal involvement, and very rarely laryngeal obstruction, can occur in patients with PC. Usually simple feeding solutions may prevent complications and failure to thrive. PMID: 31777952 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
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