Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF ‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet.

Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet. Mol Med Rep. 2019 Oct 31;: Authors: Yu Q, Xia Z, Liong EC, Tipoe GL Abstract The present study aimed to investigate the molecular mechanisms of the ameliorative effects of chronic aerobic exercise on non‑alcoholic steatohepatitis (NASH) in rat skeletal muscle. Female Sprague‑Dawley rats (n=6‑9 per group) were divided into four groups: i) Rats fed with normal chow; ii) exercise rats fed with normal chow + exercise (run on a rotarod for 30 min per day from 9‑12 weeks); iii) rats fed with a high‑fat diet (HFD); iv) rats fed with an HFD + exercise. All HFD rats were fed with an HFD consisting of 30% fat from fish oil throughout the study for 12 weeks. Exercise decreased the levels of hepatic lipogenic markers carbohydrate‑responsive element‑binding protein, fat‑specific protein 27 and liver X receptor and improved systemic glucose and insulin intolerance in the NASH animal model. The beneficial effects may have been mediated partly via the tripartite motif‑containing family protein 72 (TRIM72)/PI3K/Akt/mTOR pathway, accompanied with an upregulation of glucose transporter 4 in the skeletal muscle. The exercise regimen activated the master regulator of antioxidant enzymes, nuclear factor erythroid 2‑related factor 2, with upregulation of superoxi...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research

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In conclusion, the prepared LAF-loaded membrane is a novel formulation for the treatment of chronic and long-term pain.Graphical abstract
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Membrane ScienceAuthor(s): Miao Tian, Yuan Liao, Rong WangAbstractIn recent years, novel superwetting membranes have gained popularity for oily wastewater treatments via synergy between surface chemistry and topography. However, the water fluxes of the superwetting membranes normally decrease rapidly due to pore clogging and surface fouling, especially when treating surfactant-stabilized oil-in-water emulsions. Herein, a facile strategy is proposed to develop a superwetting thin film nanofibrous composite (TFNC) membrane with remarkable antifouling and se...
Source: Journal of Membrane Science - Category: Materials Science Source Type: research
Publication date: March 2020Source: Biomedical Signal Processing and Control, Volume 57Author(s): Arti Anuragi, Dilip Singh Singh SisodiaAbstractElectroencephalogram (EEG) signals are well used to characterize the brain states and actions. In this paper, a novel empirical wavelet transform (EWT) based machine learning framework is proposed for the classification of alcoholic and normal subjects using EEG signals. In the framework, the adaptive filtering is used to extract Time–Frequency-domain features from Hilbert–Huang Transform (HHT). The boundary detection method is used for segmenting the Fourier spectrum ...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Publication date: Available online 9 December 2019Source: Reactive and Functional PolymersAuthor(s): Jianshe Wang, Huiling Chen, Yingying Ma, Huijuan Bai, Benbing Shi, Chunli Hou, Jingtao Wang, Yifan LiAbstractPolymer functionalized nanoparticles have attracted burgeoning interests in designing and fabricating novel nanocomposite membranes for fast transport of ions or small molecules. Herein, imidazolium polymer coated graphene oxides (AImGOs), bearing different length of polymer brushes, are synthesized via ATRP technique, and thus a very high weight percentage of imidazolium polymer brushes on GO (up to 89.5%) is acquir...
Source: Reactive and Functional Polymers - Category: Chemistry Source Type: research
Publication date: Available online 9 December 2019Source: Journal of Electroanalytical ChemistryAuthor(s): Amaury F.B. Barbosa, Vinicius Del Colle, Nelson A. Galiote, Germano Tremiliosi-FilhoAbstractIn the present study, random superficial defects of the {110}-type were electrogenerated on an initially well-ordered Pt(111) single crystal electrode, by cycling the potential in the range from 0.05 to 1.30 V by 32 times in perchloric acid solution and in a scan rate of 0.05 V s−1, named as Pt(111)-32. After partial disordering of the electrode surface, it was modified by deposition of tin submonolayers in three di...
Source: Journal of Electroanalytical Chemistry - Category: Chemistry Source Type: research
This study showed that platinum exhibits better dispersion on alumina sites than silica sites. This can be due to a strong interaction between platinum and alumina, leading to a higher dispersion of platinum species. Furthermore, the addition of MC enhanced the Pt dispersion over the mullite, leading to an improvement in the catalytic performance.
Source: Brazilian Journal of Chemical Engineering - Category: Chemistry Source Type: research
ConclusionLow-dose aspirin or other NSAID use was not associated with reduced prostate cancer risk, neither overall nor according to anthropometric measures, smoking, or alcohol use. The variation according to outcome characteristics warrants further investigation.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
A new study suggests that even light alcohol consumption may increase overall cancer risk when compared to people who do not drink at all, increasing risk for various cancers by about 18 percent.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Jan 23, 2020. . Sponsored by Mid-Atlantic Association of Community Health Centers
Source: Rural events via the Rural Assistance Center - Category: Rural Health Source Type: events
There are many ways to treat a dry mouth at home, including using a humidifier, sucking on sugar-free lozenges, and trying alcohol-free mouthwash. Learn more.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Dentistry Source Type: news
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