Serum IL-10 Levels and Its Relationship with Parasitemia in Chronic Chagas Disease Patients.

Serum IL-10 Levels and Its Relationship with Parasitemia in Chronic Chagas Disease Patients. Am J Trop Med Hyg. 2019 Nov 04;: Authors: Salvador F, Sánchez-Montalvá A, Martínez-Gallo M, Sulleiro E, Franco-Jarava C, Sao Avilés A, Bosch-Nicolau P, Moure Z, Silgado A, Molina I Abstract It is known that the immunoregulatory networks in human Chagas disease play a key role in parasitemia control during the acute phase. However, little is known regarding the control of parasitemia during the chronic phase. The aim of the study was to describe the serum cytokine profile of Trypanosoma cruzi chronically infected patients and to evaluate its relationship with the presence or absence of parasitemia in peripheral blood. This is a prospective observational study where adult Chagas disease patients were included. Patients previously treated for Chagas disease, pregnant women, and immunosuppressed patients were excluded. Demographic and clinical information was collected, and T. cruzi real-time polymerase chain reaction (RT-PCR) and serum cytokine profile were determined in peripheral blood. Forty-five patients were included. Trypanosoma cruzi RT-PCR in peripheral blood resulted positive in 19 (42.2%) patients. No differences in the serum cytokine profile were found depending on cardiac or digestive involvement. However, patients with positive T. cruzi RT-PCR had a higher median concentration of IL-10 and IL-1beta and a lower median concentr...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research

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Publication date: Available online 31 October 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Lizette Rios, E. Emanuel Campos, Ramkumar Menon, M. Paola Zago, Nisha J. GargAbstractTrypanosoma cruzi (T. cruzi or Tc) is the causative agent of Chagas disease (CD). It is common for patients to suffer from non-specific symptoms or be clinically asymptomatic with acute and chronic conditions acquired through various routes of transmission. The expecting women and their fetuses are vulnerable to congenital transmission of Tc. Pregnant women face formidable health challenges because the frontl...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
by Yves Carlier, Jaime Altcheh, Andrea Angheben, Hector Freilij, Alejandro O. Luquetti, Alejandro G. Schijman, Manuel Segovia, Noemie Wagner, Pedro Albajar Vinas
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Publication date: Available online 23 August 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Claudia Herrera, Carine Truyens, Eric Dumonteil, Jackeline Alger, Sergio Sosa-Estani, Maria Luisa Cafferata, Luz Gibbons, Alvaro Ciganda, Maria Luisa Matute, Concepcion Zuniga, Yves Carlier, Pierre BuekensAbstractTrypanosoma cruzi, the causative agent of Chagas disease, exhibits a high genetic variability and has been classified into six discrete typing units (DTUs) named TcI-TcVI. This genetic diversity is believed to be associated with clinical characteristics and outcomes, but evidences supporting such associations ha...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
Authors: Li X, Fang Y Abstract Preeclampsia is a complication of pregnancy characterized by new-onset hypertension and proteinuria of gestation, with serious consequences for mother and infant. Although a vast amount of research has been performed on the pathogenesis of preeclampsia, the underlying mechanisms of this multisystemic disease have remained to be fully elucidated. Data were retrieved from Gene Expression Omnibus database GSE40182 dataset. After data preprocessing, differentially expressed genes of placental cells cultured in vitro from preeclampsia and normal pregnancy were determined and subjected to K...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
ez AF Abstract Chagas disease remains a major impediment to sustainable socioeconomic development in Latin America. Transplacental transmission explains the persistence of transmission in urban areas, in non-endemic regions, and in areas with an established interrupted vectorial transmission. One of every five cases of congenital Chagas disease in the world occurs in Colombia and Venezuela. The massive migration of impoverished populations from neighboring Venezuela has worsened the situation creating a humanitarian crisis in Northeastern Colombia, including the Sierra Nevada de Santa Marta. The prevalence of Chag...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
AbstractPurpose of ReviewChagas disease is endemic to all seven Central American countries, where 12% of the population lives in areas where the disease is a risk. While neglect is a pervasive characteristic of Chagas disease in general, it tends to be especially overlooked in Central America, with more studies and resources devoted to the disease in South America. Here we report on the current epidemiological scenario of Chagas disease in Central America with the objective of presenting a panorama that includes national program details, recent morbidity data, new findings, and events relevant to the disease.Recent Finding...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
Conclusions/SignificanceOur analysis suggests a disease burden forT.cruzi infection higher than previously recognized, highlighting the urgency of establishing Chagas disease surveillance and control as a key national public health priority in Mexico, to ensure that it does not remain a major barrier to the economic and social development of the country's most vulnerable populations.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
We present the case of a woman with 24 gestational weeks presenting fever, hepatosplenomegaly, pancytopenia, and inversion of albumin/globulin ratio. Anti-rK39 was positive and amastigotes were visualized on myelogram. Treatment with LAmB showed disease improvement. The newborn was born healthy at term, with delivery performed without complications. As VL in pregnancy can progress to death and complications for the mother-fetus binomial, inclusion of VL in the differential diagnosis of patients from endemic areas with compatible clinical picture is mandatory. Treatment with LAmB demonstrates safety and high cure rates in pregnancy.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research
Background: Because of the increasing migrations to Buenos Aires from Chagas disease endemic regions, it is important to know the disease prevalence due to its impact in other public health areas. According to Programa Nacional de Chagas (PNCh), general prevalence in Argentina in 2010 was 4%; prevalence in blood donors (BD) was 1,9-3,8% (Hemocentro Buenos Aires, 2012), with a prevalence of 0,61-2,87% in pregnant women (PW) (Cesacs 11, 15 and 39; 2009). As far as we know, there is no report of prevalence of positive Chagas serology (CHS) for Buenos Aires general hospitals.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: UMP. 333 Source Type: research
Background: Congenital Chagas disease (CCh) is caused by the protozoan Trypanosoma cruzi that can be vertically transmitted from infected women to their babies during pregnancy or childbirth. At most 1200 babies/year are born with CCh in Argentina, however less than 25% of cases are detected, due to diagnosis limitations. We recently developed the “AMI-test”, a Loop-mediated Isothermal Amplification (LAMP) test for CCh detection. This is a simple test, with high analytical sensitivity and specificity, adapted to newborn screening (NS).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: UMP. 590 Source Type: research
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