Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition.

Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition. Nat Prod Res. 2019 Nov 08;:1-5 Authors: Alaribe CS, Esposito T, Sansone F, Sunday A, Pagano I, Piccinelli AL, Celano R, Cuesta Rubio O, Coker HA, Nabavi SM, Rastrelli L, Picerno P Abstract Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against α-amylase and α-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products. PMID: 31698954 [PubMed - as supplied by publisher]
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research

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