Regulation of Immune Activation by Optical Control of TLR1/2 Dimerization.

Regulation of Immune Activation by Optical Control of TLR1/2 Dimerization.
Chembiochem. 2019 Nov 08;:
Authors: Hu HG, Chen PG, Wang G, Wu JJ, Zhang BD, Li WH, Davis RL, Li YM
Abstract
The activation of toll like receptors (TLRs) plays important roles in the immune response. The ability to control the activities of TLRs could be used as a switch for immune response. Herein, we rationally designed and synthesized a photoswitchable Pam3CSK4 derivative (P10) to control the activation of TLR1/2. The ground state trans-P10 could stimulate and activate antigen-presenting cells (APCs) through promoting the TLR1/2 dimerization. However, the cis-P10, derived from UV irradiation of trans-P10, reduced the activities of APCs by impeding the TLR1/2 dimerization. In the absence of UV radiation, the cis-P10 slowly returned to its ground trans state, restoring the activities of the APCs stimulating. Our results indicated that the optical control of TLR1/2 dimerization mediated by the photoswitchable P10 holds potential to regulate the immune activation and inflammation.
PMID: 31702879 [PubMed - as supplied by publisher]

Source: Chembiochem - November 7, 2019 Category: Biochemistry Authors: Hu HG, Chen PG, Wang G, Wu JJ, Zhang BD, Li WH, Davis RL, Li YM Tags: Chembiochem Source Type: research