Comparison of data-acquisition modes with Orbitrap high resolution mass spectrometry (HRMS) for targeted and non-targeted residue screening in aquacultured eel.

CONCLUSION: For residue screening, AIF has fast MS1 scan speed with adequate detection of product ions, but may lead to false positive findings. DIA methods are better suited to monitor for both targeted and non-targeted compounds because they generate more characteristic MS2 spectra for retrospective library searching. For follow-up targeted analysis, PRM is prefered over DDMS2 when searching for a limited set of compounds. PMID: 31702084 [PubMed - as supplied by publisher]
Source: Rapid Communications in Mass Spectrometry : RCM - Category: Chemistry Authors: Tags: Rapid Commun Mass Spectrom Source Type: research