Light chain only variant of proliferative glomerulonephritis with monoclonal immunoglobulin deposits is associated with a high detection rate of the pathogenic plasma cell clone

IgG (mainly IgG3) is the most commonly involved isotype in proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Here we describe the first series of PGNMID with deposition of monoclonal immunoglobulin light chain only (PGNMID-light chain). This multicenter cohort of 17 patients presented with nephritic or nephrotic syndrome with underlying hematologic conditions of monoclonal gammopathy of renal significance (71%) or multiple myeloma (29%). Monoclonal immunoglobulin was identified by serum and urine immunofixation in 65% and 73%, respectively, with abnormal serum free light chain in 83%, and a detectable bone marrow plasma cell clone in 88% of patients.

Source: Kidney International - November 8, 2019 Category: Urology & Nephrology Authors: Samih H. Nasr, Christopher P. Larsen, Christophe Sirac, Jason D. Theis, Camille Domenger, Sophie Chauvet, Vincent Javaugue, Jonathan J. Hogan, Samar M. Said, Surendra Dasari, Julie A. Vrana, Ellen D. McPhail, Lynn D. Cornell, Eve Vilaine, Ziad A. Massy, J Tags: Clinical Investigation Source Type: research