Pharmacokinetic comparisons of two different varenicline formulations in humans: Varenicline tartrate versus varenicline oxalate 

CONCLUSION: The results of the present study reveal that varenicline oxalate and varenicline tartrate have similar pharmacokinetic characteristics as varenicline, and that these two formulations exhibit pharmacokinetic equivalence to meet the regulatory criteria. Both varenicline formulations were generally well tolerated.
. PMID: 31699211 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research

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AbstractPremature ventricular complexes (PVCs) are common arrhythmias in the clinical setting. PVCs in the structurally normal heart are usually benign, but in the presence of structural heart disease (SHD), they may indicate increased risk of sudden death. High PVC burden may induce cardiomyopathy and left ventricular (LV) dysfunction or worsen underlying cardiomyopathy. Sometimes PVCs may be a marker of underlying pathophysiologic process such as myocarditis. Identification of PVC burden is important, since cardiomyopathy and LV dysfunction can reverse after catheter ablation or pharmacological suppression. This state-of...
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
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Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
AbstractItacitinib is a JAK1 ‐selective inhibitor in phase 3 development in graft‐versus‐host disease. A post hoc electrocardiogram (ECG) analysis and a plasma concentration‐QTc (C‐QTc) analysis were performed to assess cardiac safety using data from the first‐in‐human itacitinib study. The study included 2 cohort s of 12 healthy participants each in an interleaving dosing design with single doses of 10‐300 mg or placebo; 500 and 1000 mg doses were subsequently added with 12 participants randomized to itacitinib or placebo. Continuous Holter recordings were collected from 1 hour predose to 8 hours postdose ...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
CONCLUSIONS: Acute tVNS alters the recognition of briefly presented facial expressions of negative valence in adolescents with MDD while generally increasing emotion recognition in controls. tVNS seems to specifically alter early visual processing of stimuli of negative emotional valence in MDD. These findings suggest a potential therapeutic benefit of tVNS in adolescent MDD that requires further evaluation within clinical trials. PMID: 31818339 [PubMed - as supplied by publisher]
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
The standard for ambulatory arrhythmia detection in children is the Holter monitor. The Zio XT ® (Zio) patch has been FDA-approved for use in adults. However, its utility in children has not been directly compared to the Holter. We studied the ability to detect arrhythmias and patient comfort of the Zio versus the Holter in children. Patients
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
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Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
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Source: Drugs - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
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