Use of the basophil surface marker CD203c in the diagnosis of fungal sensitization in patients with cystic fibrosis

Use of the basophil surface marker CD203c in the diagnosis of fungal sensitization in patients with cystic fibrosisConference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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ns DA Abstract Pseudomonas aeruginosa (Pa) and Aspergillus fumigatus (Af), the commonest bacterium and fungus in compromised host airways, compete for iron (Fe). The Pseudomonas quinolone signal (PQS), a Pa quorum sensing molecule, also chelates Fe, and delivers Fe to the Pa cell membrane using Pa siderophores. In models of Af biofilm formation or preformed biofilms, PQS inhibited Af in a low Fe environment. AfΔsidA (mutant unable to produce siderophores) biofilm was more sensitive to PQS inhibition than wild-type (WT), as was planktonic AfΔsidA growth. PQS decreased WT Af growth on agar. All these inh...
Source: Microbiology - Category: Microbiology Authors: Tags: Microbiology Source Type: research
Background: Aspergillus lung disease may be associated with either the development of, or complicate, non-cystic fibrosis bronchiectasis (NCFB). Whilst IgE to aspergillus may support a diagnosis of Allergic Bronchopulmonary Aspergillosis, the significance of IgG to aspergillus (IgG asp) in NCFB is unclear.Method: A retrospective case series reviewing 102 patients diagnosed with NCFB, seen in a specialist secondary care bronchiectasis clinic in 2015. 60.8% had a previous IgG asp performed. 16 (25.8%) patients had elevated (≥40mgA/L) IgG asp (high group) and 46 (74.2%) patients had normal (
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Usually B is perceived as a purely neutrophilic disease. However, eosinophilic type of inflammation is observed in pts with B in clinical practice. The aim of the study was to determine the correlation between blood eosinophils level and sensitization to Aspergillus fumigatus (AF).Methods: The study included cohort of pts with confirmed by HRCT B. Peripheral blood eosinophils were counted in stable phase. Total serum IgE was evaluated by using conventional electrochemiluminescence immunoassay (ECLIA) and specific IgE to AF was measured by immunoCAP technology. The methods of descriptive statistics and non-parametric statis...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Aim: To investigate the role of different types of bronchial infection and respiratory symptoms upon lung function decline.Methods: 89 children and adults with CF (mean (SD) age: 11.71 (6) years) performed 1340 serial Multiple Breath Washout (MBW) tests and 980 spirometries over a 5-year period. Respiratory symptoms (cough, sputum, nasal congestion) and Pulmonary Exacerbations (PEx) were recorded. Pseudomonas Aeruginosa, Staphylococcus aureus infection, as well as aspergillus, candida, Achromobacter, Acinetobacter, Serratia and Stenotrophomonas Maltophilia isolated from cough swabs/ sputum cultures were recorded.Results: M...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Conclusion: Our study did not demonstrate a difference in the trend FEV1 Z score for patients with aspergillus treated for ABPA and those with aspergillus found on respiratory secretions who were not diagnosed or treated for ABPA.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Abstract RATIONALE: Recent data show that Aspergillus species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown. OBJECTIVES: We aimed to evaluate longitudinal associations between Aspergillus infections and lung disease in young children with CF. METHODS: Longitudinal data on 330 children participating in the Australian Respiratory Early Surveillance Team for Cystic Fibrosis surveillance program between 2000-2018 who underwent annual chest computed tomography (CT) and bronchoalveolar lavage (BAL) were used to determine t...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
Conclusions. The applied diagnostic criteria had no significant effect on the reported rate of ABPA prevalence. PMID: 31702121 [PubMed - as supplied by publisher]
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
In this study we combine genetic approaches and GC-MS-mediated volatile analysis to show that A. fumigatus assimilates VSCs via cysteine (CysB)- or homocysteine (CysD)-synthase. This process is essential for utilization of VSCs as sulfur sources, since P. aeruginosa-derived VSCs trigger growth of A. fumigatus wild-type, but not of a ΔcysBΔcysD mutant, on sulfur-limiting media. P. aeruginosa produces VSCs when infecting Galleria mellonella and co-infection with A. fumigatus in this model results in a synergistic increase in mortality and of fungal and bacterial burdens. Interestingly, the increment in mortality ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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