Analysis of NR5A1 in 142 patients with premature ovarian insufficiency, diminished ovarian reserve, or unexplained infertility

Ovarian reserve represents the number of available follicles/oocytes within ovaries and this can be assessed by measuring follicle stimulating hormone (FSH) levels, anti-M üllerian hormone (AMH) levels, and/or antral follicle count (AFC) determined by ultrasound [1]. AMH is produced in women by the granulosa cells of developing follicles and represents a marker of ovarian reserve that can be used in assisted reproduction and for prediction of menopausal age, probabil ity of natural conception, assessment of ovarian function after gonadotoxic treatment or diagnosis of polycystic ovarian syndrome [2], although its reliability in these roles is limited by a lack of evidence that it predicts implantation, pregnancy or live birth [3,4].

Source: Maturitas - November 8, 2019 Category: Primary Care Authors: Sylvie Jaillard, Rajini Sreenivasan, Marion Beaumont, Gorjana Robevska, Christ èle Dubourg, Ingrid M. Knarston, Linda Akloul, Jocelyn van den Bergen, Sylvie Odent, Brittany Croft, Guilhem Jouve, Sonia R. Grover, Solène Duros, Céline Pimentel, Marc-Anto Source Type: research