Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson ’s disease

Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson ’s disease (PD). Recently, more than fifty o...

Source: Molecular Neurodegeneration - November 8, 2019 Category: Neurology Authors: Mylene Huebecker, Elizabeth B. Moloney, Aarnoud C. van der Spoel, David A. Priestman, Ole Isacson, Penelope J. Hallett and Frances M. Platt Tags: Research article Source Type: research