Specific knockout of p85α in brown adipose tissue induces resistance to high-fat diet–induced obesity and its metabolic complications in male mice

ConclusionsOur results provide new mechanisms involved in the resistance to obesity development, supporting the hypothesis that the gain of BAT activity induced by the lack of p85α has a direct impact on the prevention of diet-induced obesity and its associated metabolic complications.Graphical abstractScheme of mechanisms involved in the improvement of obsesity and its associated metabolic complications in BATp85αKO mice. the lack of p85αa in BAT improves its functionality,the lipid accumulation in liver, the inflammatory profile of adipose organ,and also it induces iWAT browning.All of them would be processes that might help to understand how the gain of activity and function of BAT due to p85α loss might provoke the resistance to obesity development and its metabolic complications (e.g.insulin resistance).
Source: Molecular Metabolism - Category: Endocrinology Source Type: research