Beyond basal-bolus insulin regimen: is it still the ultimate chance for therapy in diabetes?

All people with type 1 diabetes (T1D) need insulin to survive, with the hope to cut or slow down the devastating long-term micro and macrovascular complications. About one fourth of people with type 2 diabetes (T2D) uses insulin, either as the only antyhyperglycemic drug, or in combination with other glucose-lowering medications [1,2]. Every day, about 6 million diabetic people in the U.S. inject insulin to control their hyperglycemia.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research

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Conclusions Supporting the mechanisms of NO bioavailability via exogenous application of iNOS and L-arginine significantly attenuated I/R-induced alterations in a skin flap rat model. This pharmacologic preconditioning could be an easy and effective interventional strategy to uphold conversation of L-arginine to NO even on ischemic and type 1 diabetic conditions.
Source: Annals of Plastic Surgery - Category: Cosmetic Surgery Tags: Research Source Type: research
ConclusionPatients with T1D have a higher risk of ST/FS fractures compared with sex- and age-matched controls. Since a proportion of ST/FS fractures are classified as AFFs, this could point towards the fact that AFFs also are increased in patients with T1D, but not T2D.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
This study was registered with PROSPERO, number CRD42018105220.Results: Twenty-five studies involving 537 animals were included. There was significant association of rhein with levels of blood glucose (P
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Prevalens av diabetes blant gravide og svangerskapsutfall i Nordland og Troms 2004–15. Tidsskr Nor Laegeforen. 2019 Dec 10;139(18): Authors: Leeves LT, Andreasen C, Marrable S, Glasø MU, Rostad MK, Olsen IP, Bjørnerem Å Abstract BACKGROUND: The aim was to investigate the prevalence of gestational diabetes and pregnancy outcomes in women with gestational diabetes in Nordland and Troms counties. MATERIAL AND METHOD: We included all 1 067 women with type 1 diabetes, type 2 diabetes and gestational diabetes among 34 915 births at four hospitals in Nordland and Troms counties...
Source: Tidsskrift for den Norske Laegeforening - Category: General Medicine Authors: Tags: Tidsskr Nor Laegeforen Source Type: research
This article discusses the available CGM and insulin pump systems and the clinical benefits of their use in adults with type 1 diabetes, intensively insulin-treated type 2 diabetes, and pregnant patients with preexisting diabetes.
Source: Endocrinology and Metabolism Clinics of North America - Category: Endocrinology Authors: Source Type: research
According to a study published inDiabetologia, preterm birth may increase risk of developing type 1 and type 2 diabetes in adulthood.Med Page Today
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Publication date: Available online 7 December 2019Source: Trends in Endocrinology &MetabolismAuthor(s): Jennifer R. Snaith, Deborah J. Holmes-Walker, Jerry R. GreenfieldIndividuals with type 1 diabetes (T1D) frequently fail to achieve glycemic goals and have excess cardiovascular risk and premature death. Adjunctive agents may play a role in reducing morbidity, mortality, and the adverse sequelae of insulin treatment. A surge in type 2 diabetes drug development has revealed agents with benefits beyond glucose lowering, including cardiovascular risk reduction. Could these benefits translate to T1D? Specific trials for T...
Source: Trends in Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ConclusionsThe clinical decision regarding timing of delivery is complex and contingent on maternal ‐fetal wellbeing, including adequate glycemic control. This study suggests that delivery at 38, 39 or 40 weeks’ gestation may optimize neonatal outcomes among women with diabetes.
Source: Acta Obstetricia et Gynecologica Scandinavica - Category: OBGYN Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Conclusions: Our estimated rates of prevalence of GP in T1DM and T2DM indicate that GP is not a common clinical complication in these populations. Majority of EMRs that indicated a diagnosis of GP did not include any documentation of definitive diagnostic testing (EGD and/or GES).
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ALIMENTARY TRACT: Original Articles Source Type: research
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