Purification of ginseng rare sapogenins 25-OH-PPT and its mechanism of hypoglycemic, anti-inflammatory and lipid-lowering activities

ConclusionResearch found that 25-OH-PPT can reduce blood glucose and enhance glucose tolerance in STZ model mice. It increases insulin sensitivity by upregulating GLUT4 and AMPK in skeletal muscle, and activating insulin signaling pathways. In DB/DB mice, 25-OH-PPT achieves hypoglycemic effects mainly by activating the insulin signaling pathway. Meanwhile, through the influence of liver inflammatory factors and lipids in serum, it can be seen that 25-OH-PPT has obvious anti-inflammatory and lipid-lowering effects. These results provide new insights into the study of ginseng as a functional food.Graphical abstract
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research