Preparation and in vitro antibacterial properties of anodic coatings co-doped with Cu, Zn, and P on a Ti–6Al–4V alloy

In this study, copper (Cu) and zinc (Zn) as well as phosphorus (P) were co-doped into a Ti–6Al–4V titanium alloy via micro-arc oxidation (MAO). The entrance mechanisms of Cu and Zn into MAO coatings were investigated by an orthogonal experiment. The results show that Cu and Zn in Cu–Zn–P coatings separately exist mainly in the forms of Cu2O and Zn3(PO4)2. The Cu content in MAO coating increases with increasing EDTA-CuNa2 and KOH concentrations and decreasing phytic acid concentration but is nearly independent of EDTA-ZnNa2 concentration. The Zn content increases with increasing EDTA-ZnNa2 concentration and decreasing EDTA-CuNa2 concentration, indicating the competing effect between Cu and Zn for incorporation into Cu–Zn–P coatings. Compared with Zn ions, Cu ions do not readily enter anodic coatings due to their simultaneous involvement in coating formation on the anode and precipitation of metallic copper on the cathode. Cu–Zn–P coatings with appropriate amounts of Cu and Zn achieve excellent antibacterial ability against Escherichia coli (E.coli), Staphylococcus aureus (S.aureus), and Methicillin-resistant Staphylococcus aureus (MRSA). These antibacterial properties, in addition to excellent cytocompatibility, make Cu–Zn–P coatings as promising materials for orthopedic applications.
Source: Materials Chemistry and Physics - Category: Materials Science Source Type: research

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CONCLUSION: Our data showed the potential of this series for exploring new and more effective antibacterial in order to develop in vivo and against other resistant bacteria. PMID: 31820692 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Abstract BACKGROUND: A porous Ti6Al4V implant that is manufactured using selective laser melting (SLM) has broad potential applications in the field of orthopaedic implants. The pore structure of the SLM porous Ti6Al4V implant allows for cell migration and osteogenic differentiation, which is favorable for bone ingrowth and osseointegration. However, it is unclear whether the pore structure and partially melted Ti6Al4V particles on a SLM porous Ti6Al4V implant will increase bacterial adhesion and, perhaps, the risk of implant-related infection. QUESTIONS/PURPOSES: (1) Is there more bacterial adhesion and colo...
Source: Clinical Orthopaedics and Related Research - Category: Orthopaedics Authors: Tags: Clin Orthop Relat Res Source Type: research
Publication date: Available online 26 November 2019Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Ayşenur Aygün, Fulya Gülbağça, Mehmet Salih Nas, Mehmet Hakkı Alma, Mehmet Harbi Çalımlı, Buket Ustaoglu, Yasemin Celik Altunoglu, Mehmet Cengiz Baloğlu, Kemal Cellat, Fatih ŞenAbstractThis paper reports the anticarcinogenic and antimicrobial properties of silver nanoparticles (Ag NPs) obtained by green synthesis using the extract of Rheum ribes (R. ribes), a medicinal plant. For the synthesis of Ag NPs, the ethanolic extracts of R. ribes were used as a reducing as well as th...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
In this study, Ag-MgO nanocomposites were bio-modified by different concentrations of Artemisia haussknechtii medicinal plant and Protoparmeliopsis muralis medicinal lichen extracts. Determination of physicochemical properties of NCs were carried out by UV-Visible spectroscopy, scanning electron microscope (SEM), X-ray powder diffraction (XRD), and Fourier transform infrared (FT-IR) analyses. Antibacterial effects of NCs against methicillin-resistant Staphylococcus aureus (MRSA), E. coli ATCC 25922, and P. aeruginosa ATCC 27853 bacteria were measured by disc diffusion and minimum inhibition/bactericidal concentrations (MIC...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
Publication date: Available online 5 November 2019Source: Inorganica Chimica ActaAuthor(s): Mousumi Nayak, Ashish Kumar Singh, Pradyot Prakash, Rajni Kant, Subrato BhattacharyaAbstractThiosalicylato complexes of Zn(II) and Hg(II), [Zn(SC6H4CO2)(TMEDA)]2 (1) and [TMEDA-H2][Hg(SC6H4CO2)2] (2) where (TMEDA = N,N,N',N'-tetramethylethylenediamine) have been synthesized and characterized by spectral and single crystal X-ray analyses. Thiosalicylate opted different binding modes; in 1 all three binding sites are used whereas in 2 bonding of the ligands are mainly through S atoms, however, Hg-O distances indicate the existence...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
In this study, a green synthesis approach was used to create a composite hydrogel (CoHy) of RSF stabilized with CarboxymethylCellulose-Na (CMC-Na) and loaded with AgNPs. Their swelling ratios were up to 59 g/g when tested in different physiologically relevant fluids. Material characterizations by Scanning electron microscopy (SEM) with Energy Dispersive X-ray Spectroscopy (EDS), and X-Ray Diffraction (XRD) confirmed the presence of AgNPs on the surface. Antimicrobial properties of the CoHy samples were evaluated using agar diffusion tests. The results showed distinct inhibition zones against major microorganisms found in...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 5 November 2019Source: Inorganica Chimica ActaAuthor(s): Mousumi Nayak, Ashish Kumar Singh, Pradyot Prakash, Rajni Kant, Subrato BhattacharyaAbstractThiosalicylato complexes of Zn(II) and Hg(II), [Zn(SC6H4CO2)(TMEDA)]2 (1) and [TMEDA–H2][Hg(SC6H4CO2)2] (2) where (TMEDA = N,N,N',N'-tetramethylethylenediamine) have been synthesized and characterized by spectral and single crystal X-ray analyses. Thiosalicylate opted different binding modes; in 1 all three binding sites are used whereas in 2 bonding of the ligands are mainly through S atoms, however, Hg-O distances indicate the existen...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research
Publication date: Available online 31 October 2019Source: SteroidsAuthor(s): Anna Yu. Spivak, Rezeda R. Khalitova, Darya A. Nedopekina, Rinat R. GubaidullinAbstractA series of 34 new amine- and guanidine-functionalized derivatives of betulinic, ursolic, and oleanolic acids were synthesized and tested for their antimicrobial activity against the growth of four bacterial strains (Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus (MRSA)) and two fungal strains (Candida albicans and Cryptococcus neoforman). The obtained compounds were also tested for the cytotoxic effect against HEK29...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
rik The present study aimed to identify the chemical constituents and to assess the in-vitro, antimicrobial, anticancer, antioxidant, metabolic enzymes and cyclooxygenase (COX) inhibitory properties of essential oil (EO) of Stachys viticina Boiss. leaves. The S. viticina EO was isolated and identified using microwave-ultrasonic and GC-MS techniques, respectively. Fifty-two compounds were identified, of which endo-borneol was the major component, followed by eucalyptol and epizonarene. The EO was evaluated against a panel of in-vitro bioassays. The EO displayed antimicrobial activity against methicillin-resistant Staphy...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: 15 January 2020Source: Catalysis Today, Volume 340Author(s): Sami Rtimi, John KiwiAbstractThis review focuses on the acceleration of the bactericidal and fungicidal effects by uniform, adhesive Cu-based nanocomposites on textile and thin polymer surfaces. The acceleration of the bacterial inactivation kinetics mediated by Cu, TiO2/Cu and ZrO2-TiO2-Cu films in aerobic and anaerobic media is discussed for Gram negative, Gram positive bacteria and fungi. The Cu induced bacterial inactivation kinetics in the dark was observed to occur within the minute range for diverse bacteria. The characterization of the i...
Source: Catalysis Today - Category: Chemistry Source Type: research
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