Dynamic synergetic configurations of resting-state networks in ADHD

In this study, we proposed a dynamical systems perspective to assess how the DMN over time recruits different configurations of network segregation and integration. Specifically, we were interested in configurations for which both intra- and inter-network connections are retained, as opposed to commonly used methods which assess network segregation as a single measure. From resting-state fMRI data, we extracted three different stable configurations of FC patterns for the DMN, namely synergies. We provided evidence supporting our hypothesis that ADHD differs compared to controls, both in terms of recruitment rate and topology of specific synergies between resting-state networks. In addition, we found a relationship between synergetic cooperation patterns of the DMN with cognitive control networks and a behavioral measure which is sensitive to ADHD-related symptoms, namely the Stroop color-word task.
Source: NeuroImage - Category: Neuroscience Source Type: research