Splenic marginal zone lymphoma treated with laparoscopic splenectomy: A case report

CONCLUSIONPatients with SMZL is usually expected to have good prognosis with splenectomy. However, careful follow-up is required for aggressive transformation can occur and result in worse prognosis.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research

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Condition:   Lymphoma Intervention:   Other: Quality of life Sponsors:   University Hospital, Toulouse;   Force Hémato;   Hospitalidee Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Advanced Solid Tumor;   Lymphoma Intervention:   Drug: ALPN-202 Sponsor:   Alpine Immune Sciences, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The objective of this pharmacogenetic study was to investigate the relationship of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with methotrexate (MTX) induced toxicities and plasma homocysteine level in Acute Lymphoblastic Leukemia (ALL) patients of Bangladesh. Several polymorphisms result in reduced MTHFR activity that causes impaired remethylation of homocysteine to methionine and abnormal MTX metabolism especially in tissues with high turnover. Therefore, the risk of elevated plasma homocysteine as well as MTX induced toxicities become higher with MTHFR polymorphisms.Patients and MethodsWe recruited 1...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
ConclusionsIn this cohort of young women, population-based cancer registry data on chemotherapy receipt was reasonably accurate and complete in comparison with insurance claims. Radiation and hormone therapy appeared to be less complete.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
In conclusion, the anti-proliferative effects of SFN indicate its potential as a new substance for the treatment of PEL. PMID: 31787726 [PubMed - in process]
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
This report strengthens the hypothesis of a common lymphoid progenitor which accumulates genetic alterations leading to two different hematologic malignant diseases with significa ntly distinct prognoses.
Source: Virchows Archiv - Category: Pathology Source Type: research
Opinion statementDespite being the second most common indolent non-Hodgkin ’s lymphoma (iNHL), marginal zone lymphoma (MZL) remains largely understudied, and given its underlying disease heterogeneity, it is challenging to define a single treatment approach for these patients. For localized disease, local therapy is recommended such as triple therapy forH.pylori in gastric extranodal MZL, splenectomy for splenic MZL, and radiotherapy for nodal MZL. For disseminated disease with low tumor burden, a watch and wait or single-agent rituximab can be used. However, for symptomatic disease, a similar approach to follicular ...
Source: Current Treatment Options in Oncology - Category: Cancer & Oncology Source Type: research
Publication date: 3 December 2019Source: Cell Reports, Volume 29, Issue 10Author(s): Hamidullah Khan, Ashish Anshu, Aman Prasad, Sushmita Roy, Justin Jeffery, Wasakorn Kittipongdaja, David T. Yang, Stefan M. SchiekeSummaryMetabolic flexibility allows cells to adapt to various environments and limits the efficacy of metabolic drugs. Therapeutic targeting of cancer metabolism relies on defining limiting requirements and vulnerabilities in the highly dynamic metabolic network. Here, we characterize the metabolic reprogramming and identify cancer-specific metabolic vulnerabilities in response to the pharmacological inhibition ...
Source: Cell Reports - Category: Cytology Source Type: research
Abstract LSP1 (Lymphocyte-specific protein 1) protein plays an important role in neutrophil motility, fibrinogen matrix proteins adhesion, and trans-endothelial migration. Variation in the LSP1 gene is associated with leukemia and lymphomas in tumor cells of Hodgkin's disease and breast cancer. Despite extensive study on the human LSP1, a comprehensive analysis on the Single Nucleotide Polymorphism (SNPs) of the gene is not available. Therefore, it is of interest to identify, collect, store and analyze the SNPs of the LSP1 gene in relation to several known diseases. Hence, the SNP data (398 rsids) from dbSNP datab...
Source: Bioinformation - Category: Bioinformatics Authors: Tags: Bioinformation Source Type: research
Conditions:   Non Hodgkin Lymphoma;   Mantle Cell Lymphoma Interventions:   Biological: 8-Day Production of Car-T Cells;   Biological: 12-Day Production of Car-T Cells Sponsor:   Medical College of Wisconsin Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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