GNA11 joins GNAQ and GNA14 as a recurrently mutated gene in anastomosing hemangioma

In this study, we investigated the clinicopathological and molecular features of 26 AHs. By Sanger sequencing and MassARRAY analysis, mutually exclusive mutations in exon 5 ofGNAQ,GNA11, andGNA14 were identified in 10, 5, and 5 tumors, respectively, of the 22 investigated tumors, with an overall mutation rate of 91%. No notable differences in the clinicopathological features were observed betweenGNAQ-,GNA11-, orGNA14-mutated tumors. Our results implicatedGNA11 mutations, as well as previously known mutations of its paraloguesGNAQ andGNA14, as essential drivers in the pathogenesis of AH.
Source: Virchows Archiv - Category: Pathology Source Type: research