Corneal Endothelial Blebs Induced in Scleral Lens Wearers
SIGNIFICANCE
In the bleb phenomenon, some endothelial cells transiently lose their specular reflection. This has been reported during contact lens wear and goggle-induced hypoxia or hypercapnia.
PURPOSE
The purposes of this study were to determine whether blebs appear after scleral lens wear and if their appearance is influenced by lens clearance and to compare bleb and cell sizes.
METHODS
Twenty-one subjects were fitted with two similar scleral lenses with different targeted clearances of 200 and 400 μm (the SL200 and SL400, respectively). Each lens was worn unilaterally for 25 minutes, whereas the other eye served as a control. Before and after lens wear, the endothelium was photographed using specular microscopy. The number of blebs and measurements of the areas of cells and blebs were analyzed. Paired t tests compared differences in the areas of cells and blebs. Differences in median bleb number were evaluated using the Wilcoxon test.
RESULTS
After wearing the SL200 and SL400 lenses, respectively, 9 and 14 subjects had at least one bleb. The median bleb number after wearing lenses was significantly different (SL200, 0.00; SL400, 1.00; P = .02). Bleb and cell areas were significantly different (blebs, 293 ± 28; cells, 370 ± 32 μm2; P
Source: Optometry and Vision Science - Category: Opthalmology Tags: FEATURE ARTICLE – PUBLIC ACCESS Source Type: research