Frozen-thawed embryo transfer is better than fresh embryo transfer in GnRH antagonist cycle in women with 3 –10 oocytes retrieved: a retrospective cohort study
AbstractPurposeTo compare the clinical outcome of fresh embryo transfer with frozen-thawed embryo transfer in subsequent cycle of GnRH antagonist protocol.MethodsTotally, 1430 women were enrolled from the cases of our Assisted Reproduction Center from January 2015 to January 2019 for this retrospective cohort study. The inclusion criteria of the subjects included women with ages under 40 years, 3–10 oocytes retrieved, good embryo quality according to gardener score, GnRH antagonist protocol, underwent first cycle of fresh embryo transfer or freeze-all strategy and transferred in subsequent cycle. However, the patients with endometriosis, PGD/PGS cycles, history of recurrent preg nancy loss and uterine pathology were excluded. 495 women of group I underwent fresh embryo transfer in first cycle and 935 patients of group II received frozen-thawed transfer in subsequent cycle. The primary outcome was clinical pregnancy rate. A logistic regression analysis was performed to deter mine the variables that could be independently associated with clinical pregnancy rate. Models were adjusted for covariates including patients’ age, fertilization type, infertility type, infertility duration, the number of oocytes retrieved, the number of embryos transferred and type of embryo tra nsferred.ResultsClinical pregnancy rate was significantly higher in frozen-thawed embryo transfer than in fresh embryo transfer (63.70% vs. 54.50%,p
CONCLUSION: There was no significant difference in clinical pregnancy rates when urinary LH and hCG trigger as methods to time insemination were compared in women undergoing gonadotropin stimulated IUI. This article is protected by copyright. All rights reserved. PMID: 31169952 [PubMed - as supplied by publisher]
In this study, vaginal microbiome was divided in five biotypes, being four of them dominated by lactobacilli and considered as healthy (pH 5.0) and higher diversity. In a healthy status, microbiota is balanced and forms a stable ecological unit dominated by Lactobacillus species, which fixes pH below 5.0 and controls non-desirable groups. In a pathogenic process, the microbiome shifts to a dysbiotic state, in which lactobacilli drop, pH is increased to values above 4.5 and other groups such as Gardnerella, Atopobium, Prevotella, and Streptococcus, among others, can overgrow (Srinivasan et al., 2012). Short chain fatty acid...
Publication date: Available online 19 February 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Keiji Kuroda, Yuko Ikemoto, Asako Ochiai, Rie Ozaki, Yuko Matsumura, Shuko Nojiri, Koji Nakagawa, Rikikazu SugiyamaABSTRACTStudy ObjectiveTo analyze the clinical outcomes and predictive factors for the therapeutic effect of combination treatment of preoperative embryo cryopreservation and endoscopic surgery (‘surgery-assisted reproductive technology [ART] hybrid therapy’) in infertile women with diminished ovarian reserve (DOR) with uterine fibroids and/or ovarian endometriomas.DesignA retrospective coh...
ConclusionsWomen with suspected endometriosis and aberrant endometrial BCL6 expression have worse reproductive outcomes following embryo transfer, including a high miscarriage rate, poor IR, and low LBR and CPR compared to cycles pre-treated with medical and surgical management.
ConclusionPresence of adenomyosis seems to have adverse effects on IVF outcomes in clinical pregnancy rate, live birth rate and miscarriage rate. Screening for adenomyosis might be considered before ART so that the couple has better awareness of the prognosis.
While infertility may be a problem affecting nearly 7.3 million women in the United States between the ages of 15-44, it is a topic that women often don’t discuss. Rather, they suffer from the emotional pain that accompanies hormone injections, multiple procedures, and sometimes miscarriage. How is it best to treat this vulnerable population that rarely gets the attention it deserves? The answer lies in a team approach to medicine. According to Dr. Michael Jacobs, reproductive endocrinologist and infertility expert, who is director of Fertility and IVF Center of Miami, “The best way to treat couples challenged ...
ConclusionsAmong couples of reproductive age in China, the prevalence of infertility was 25%, and almost half of the couples experiencing infertility had not sought medical help. Tweetable abstractIn China, 25% of couples actively attempting to become pregnant suffered infertility.
ConclusionsAmong couples of reproductive age in China, the prevalence of infertility was 25%, and almost half of the couples experiencing infertility had not sought medical help.This article is protected by copyright. All rights reserved.
CONCLUSIONS: Among couples of reproductive age in China, the prevalence of infertility was 25%, and almost half of the couples experiencing infertility had not sought medical help. This article is protected by copyright. All rights reserved. PMID: 29030908 [PubMed - as supplied by publisher]
Conclusion(s) Letrozole-low dose gonadotropins combination appears to be effective across different causes of infertility for superovulation. The letrozole-low dose gonadotropin combination resulted in high rate of monofolliculogenesis, low occurrence of multiple gestations and no case of OHSS or cycle cancellation.