Theme 1 Epidemiology and informatics

Volume 20, Issue sup1, November 2019, Page 101-113 .
Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Source Type: research

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We examined 28 ALS patients and 27 age-matched healthy controls. ALS patients and healthy controls underwent the nine hole peg test (NHPT) and TMS with RMT. Measurements in patients were repeated after three and six months. Results: At baseline, the median NHPT durations were 1,4-fold longer (p
Source: Neurology Research International - Category: Neurology Tags: Neurol Res Int Source Type: research
Publication date: Available online 12 December 2019Source: Journal of Clinical NeuroscienceAuthor(s): Minori Furuta, Natsumi Furuta, Kazuaki Nagashima, Yukio Fujita, Yoshito Tsushima, Yoshio IkedaAbstractIn clinical settings, it is often difficult to distinguish inclusion body myositis (IBM) from other neuromuscular diseases. In order to clarify clinically useful characteristics for making the differential diagnosis of IBM, we performed clinical, epidemiological, and neuroimaging analyses in patients with various types of neuromuscular disorders. We enrolled 333 patients with myopathy and 12 patients with amyotrophic later...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
by Nicole F. Liachko, Aleen D. Saxton, Pamela J. McMillan, Timothy J. Strovas, C. Dirk Keene, Thomas D. Bird, Brian C. Kraemer Pathological phosphorylated TDP-43 protein (pTDP) deposition drives neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP). However, the cellular and genetic mechanisms at work in pathological TDP-43 toxicity are not fully elucidated. To identify genetic modifiers of TDP-43 neurotoxicity, we utilized aCaenorhabditis elegans model of TDP-43 proteinopathy expressing human mutant TDP-43 pan-neuronally (TDP-43 tg). In TDP-43 tgC.elegans, we conducted ...
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
Excitatory amino acid transporter 2 (EAAT2) is the predominant astrocyte glutamate transporter involved in the reuptake of the majority of the synaptic glutamate in the mammalian central nervous system (CNS). Gene expression can be altered without changing DNA sequences through epigenetic mechanisms. Mechanisms of epigenetic regulation, include DNA methylation, post-translational modifications of histones, chromatin remodeling, and small non-coding RNAs. This review is focused on neurological disorders, such as glioblastoma multiforme (GBM), Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson&rsq...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
Publication date: Available online 11 December 2019Source: Trends in GeneticsAuthor(s): Lindsey D. Goodman, Nancy M. BoniniThe presence of microsatellite repeat expansions within genes is associated with>30 neurological diseases. Of interest, (GGGGCC)>30-repeats within C9orf72 are associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD). These expansions can be 100s to 1000s of units long. Thus, it is perplexing how RNA-polymerase II (RNAPII) can successfully transcribe them. Recent investigations focusing on GGGGCC-transcription have identified specific, canonical complexes that may promot...
Source: Trends in Genetics - Category: Genetics & Stem Cells Source Type: research
(CNN) — Google users in the United States had a lot of questions about blood pressure, the keto diet and hiccups in 2019. Those topics were among the 10 most-searched health-related questions on the search engine this year, according to new data from Google. The list was based on search terms collected between January and early December. Last year, the top health-related questions Googled by people in the US included what is amyotrophic lateral sclerosis, or ALS, what is endometriosis and how long does weed stay in your urine. In 2017, what is lupus, how long does the flu last and what causes hiccups were some of the...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Google Source Type: news
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Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Authors: Source Type: research
Abstract Neurodegenerative disorders present a broad group of neurological diseases and remain one of the greatest challenges and burdens to mankind. Maladies like amyotrophic lateral sclerosis, Alzheimer's disease, stroke or spinal cord injury commonly features astroglia involvement (astrogliosis) with signs of inflammation. Regenerative, paracrine and immunomodulatory properties of human mesenchymal stromal cells (hMSCs) could target the above components, thus opening new therapeutic possibilities for regenerative medicine. A special interest should be given to hMSCs derived from the umbilical cord (UC) tissue, ...
Source: Neurochemical Research - Category: Neuroscience Authors: Tags: Neurochem Res Source Type: research
Abstract Neurofilaments: light, medium, and heavy (abbreviated as NF-L, NF-M, and NF-H, respectively), which belong to Type IV intermediate filament family (IF), are neuron-specific cytoskeletal components. Neurofilaments are axonal structural components and integral components of synapses, which are important for neuronal electric signal transmissions along the axons and post-translational modification. Abnormal assembly of neurofilaments is found in several human neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), infantile spinal muscular atrophy (SMA), and hereditary sensory-motor neuropath...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
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