Table of Contents - Poster Communications

Volume 20, Issue sup1, November 2019, Page 100-100 .
Source: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration - Category: Neurology Source Type: research

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Authors: Seo DY, Heo JW, Ko JR, Kwak HB Abstract Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces microglia activation, mitochondrial dysfunction, the production of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), pro-inflammatory cytokines, and reactive oxygen species. Exercise, which plays an important role in maintaining and improving brain health, might be a highly effective intervention for preventing ...
Source: International Neurourology Journal - Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
CONCLUSIONS: Preliminary findings suggest that the RS-tDCS protocol is safe and feasible in individuals with ALS. Our protocol serves as a model for future long-term studies to evaluate the clinical and neurophysiological effects of tDCS using a telerehabilitation protocol in ALS. PMID: 31796701 [PubMed - as supplied by publisher]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
Conclusions: Students' visits to PALS may contribute to the maintenance of the QOL of the patients. Additionally, visits, with psychological support for the students, seem safe and could contribute to the students' psychological maturation as health professionals. Additional psychological support may be necessary for some students in fragile subgroups/moments.RESUMO Esclerose lateral amiotr ófica (ELA) é doença neurodegenerativa sem cura, mas tratamento multidisciplinar pode manter qualidade de vida (QOL). Embora profissionais de saúde possam ser afetados pela atuação na ELA, pouco...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Publication date: 4 December 2019Source: Neuron, Volume 104, Issue 5Author(s): Katherine M. Wilson, Bhavana Muralidharan, Adrian M. IsaacsThe (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.
Source: Neuron - Category: Neuroscience Source Type: research
Publication date: January 2020Source: Artificial Intelligence in Medicine, Volume 102Author(s): Wenping Tang, Aiqun Wang, S. Ramkumar, Radeep Krishna Radhakrishnan NairAbstractParalyzed patients were increasing day by day. Some of the neurodegenerative diseases like amyotrophic lateral sclerosis, Brainstem Leison, Stupor and Muscular dystrophy affect the muscle movements in the body. The affected persons were unable to migrate. To overcome from their problem they need some assistive technology with the help of bio signals. Electrooculogram (EOG) based Human Computer Interaction (HCI) is one of the technique used in recent ...
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Publication date: Available online 4 December 2019Source: Stem Cell ResearchAuthor(s): E.I. Ustyantseva, S.P. Medvedev, A.S. Vetchinova, S.N. Illarioshkin, S.V. Leonov, S.M. ZakianAbstractAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by death of motor neurons. To date, neither etiology nor pathogenesis of ALS are known, which leads to the absence of an effective treatment strategy. ALS patient-specific induced pluripotent stem cells (iPSCs) represent an excellent tool for the disease study. We obtained iPSCs line from peripheral blood mononuclear cells of the patient with homozygous Asp90...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Alternating motion rate (AMR) is a standard measure often included in neurological examinations to assess orofacial neuromuscular integrity. AMR is typically derived from recordings of patients producing repetitions of a single syllable as fast and clear as possible on one breath. Because the task places high demands on oromotor performance, particularly articulatory speed, AMRs are widely considered to be tests of maximum performance and, therefore, likely to reveal underlying neurologic deficits. Despite decades of widespread use, biomechanical studies have shown that speakers often circumvent the presumed speed challeng...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
an Den Bosch Growing evidence suggests that aberrant energy metabolism could play an important role in the pathogenesis of amyotrophic lateral sclerosis (ALS). Despite this, studies applying advanced technologies to investigate energy metabolism in ALS remain scarce. The rapidly growing field of metabolomics offers exciting new possibilities for ALS research. Here, we review existing and emerging metabolomic tools that could be used to further investigate the role of metabolism in ALS. A better understanding of the metabolic state of motor neurons and their surrounding cells could hopefully result in novel therapeutic strategies.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Tags: Correction Source Type: research
Associations between type 2 diabetes (T2D) and amyotrophic lateral sclerosis (ALS) were discovered in observational studies in both European and East Asian populations. However, whether such associations are c...
Source: BMC Medicine - Category: Internal Medicine Authors: Tags: Research article Source Type: research
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