Matching stimulation paradigms resolve apparent differences between optogenetic and electrical VTA stimulation

ConclusionsPreviously found large differences of electrical and optogenetic stimulation might be due to unmatched stimulation intensity, particularly relative electrical overstimulation. These findings imply that therapeutic electrical VTA stimulation might be relatively specific if employed with optimized parameters.
Source: Brain Stimulation - Category: Neurology Source Type: research

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Authors: Eckelman WC, Kuwert T, Ciarmiello A, Riondato M, Mansi L Abstract Of the many uses of radiopharmaceuticals, developing radiotracers that contribute significantly to diagnosis and therapy of patients has been a major focus. This requires a broad spectrum of expertise including that of the attending physician who lends insight to an unmet clinical need neither addressed by other imaging techniques nor by analysis of tissue, blood, and urine for diagnostics and addressed by pharmaceuticals for therapeutic applications. The design criteria have depended on radiochemistry, on matching the radiopharmaceutical wi...
Source: Quarterly Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Tags: Q J Nucl Med Mol Imaging Source Type: research
DiscussionThis research is of great significance for the treatment of cancer and improving the quality of life of cancer patients. The study may provide the most direct evidence for meeting clinical needs and lay a solid scientific foundation for later product development.Trial registrationChinese Clinical Trial Registry, ID:ChiCTR1800020107. Registered on 14 December 2018.
Source: Trials - Category: Research Source Type: clinical trials
Conditions:   Parkinsonian Syndrome;   Parkinson Disease(PD);   Multiple System Atrophy (MSA);   Progressive Supranuclear Palsy (PSP) Intervention:   Drug: DaTSCAN™ Ioflupane (123I) Injection Sponsors:   GE Healthcare;   PPD Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Lung Cancer Interventions:   Other: Hyperpolarized 129Xe MRI;   Other: Technegas V SPECT;   Other: Sputum Induction Sponsors:   McMaster University;   Cyclomedica Australia Pty Ltd;   Ontario Lung Association;   St. Joseph's Healthcare Hamilton Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Brindhaban A Abstract Rationale: Radiation dose to patients from imaging modalities are measured or calculated to assess the risk of the procedure and compared it to the benefits. Periodic review of image acquisition methods and radiation dose used are essential part of procedure optimization in medical imaging. The aim of this study was to estimate patient radiation dose from single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) using computed tomography (CT) images for attenuation correction. Methods: SPECT and CT image acquisition parameters such as, administered activity...
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
We present a 72-year-old female with an osseous metastasis to the spine, which had an atypical appearance on both nuclear medicine and radiological modalities and was misdiagnosed as an abscess. We discuss the pitfalls of bone scintigraphy and the causes of photopenic metastatic lesions. PMID: 31811064 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research
AbstractDiseases of the foot and ankle are common but relatively difficult to diagnose because of the complexity of the anatomy and the frequent occurrence of multiple diseases at the same time. For these reasons, management of chronic foot pain is often clinically challenging. MRI is the imaging modality of choice in many types of diseases causing chronic foot pain, due to high resolution and excellent soft tissue contrast. However, in the postoperative state, the use of MRI can be limited by artifact from metallic devices, and it may be difficult to confirm whether the pathology detected on the MRI is the actual cause of...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
AbstractBackgroundHigher imaging quality makes cardiac positron emission tomography (PET) desirable for evaluation of suspected coronary artery disease (CAD). High cost of PET imaging may be offset by reduced utilization and/or improved outcomes.MethodsThis retrospective observational study utilized Medicare fee-for-service dataset. Study participants had no CAD diagnosis within 1  year prior to initial imaging. The PET group (PET imaging) and propensity score matched comparison group (single photon emission computed tomography or stress echocardiography) underwent index imaging between January 2014 and December 2016....
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
ConclusionsSignificant variability of regional cardiac123I-MIBG uptake is common in cases with normal planar cardiac uptake. Heterogeneity of regional uptake appears non-specific and unlikely to aid in the diagnosis of Lewy body disease.
Source: Journal of Nuclear Cardiology - Category: Nuclear Medicine Source Type: research
Abstract68Ga-DOTATOC PET/CT is widely used as a functional imaging technique in the detection and characterization of neuroendocrine tumors (NETs). Pancreatic NET and intrapancreatic accessory spleen (IPAS) have similar radiologic characteristics in anatomical imaging and usually show high uptake of68Ga-DOTATOC. Thus, it is challenging to make a differential diagnosis between NET and IPAS when the tumor-like lesion is located in the pancreatic tail. Here, we present a case of68Ga-DOTATOC PET-positive pancreatic tail lesion with high arterial enhancement on CT and MRI. Since99mTc-labeled damaged red blood cell does not accu...
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
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