Lactose and Fructo-oligosaccharides Increase Visceral Sensitivity in Mice via Glycation Processes, Increasing Mast Cell Density in Colonic Mucosa

Irritable bowel syndrome (IBS) is characterized by abdominal pain, bloating, and erratic bowel habits. A diet low in fermentable oligo-, di-, mono-saccharides and polyols (FODMAPs) can reduce symptoms of IBS, possibly by reducing microbial fermentation products. We investigated whether ingestion of FODMAPs can induce IBS-like visceral hypersensitivity mediated by fermentation products of intestinal microbes in mice.
Source: Gastroenterology - Category: Gastroenterology Authors: Source Type: research

Related Links:

Dana Carpender, friend and author of many low-carb cookbooks, provided this review of my new Revised &Expanded Wheat Belly, below. For more of Dana’s signature wit and conversation, you can join her on her engaging Facebook page “Hold the toast press” or visit her Amazon page that lists all her wonderful low-carb cookbooks. It’s funny how things happen. Nine years ago I had already been eating a low carbohydrate diet for 16 years. During that time I had occasionally eaten low carb tortillas and low carb bread. These things were hardly a staple of my diet, but I kept ’em around for the occ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open autoimmune joint pain wheat belly Source Type: blogs
AbstractBackgroundThe symptoms of irritable bowel syndrome (IBS) lead to considerable impairment of health-related quality of life and high health care costs. Available therapies are not efficient in treating the symptoms of IBS. Studies have shown the beneficial effects ofSaccharomyces cerevisiae CNCM I-3856. Therefore, this study was done to evaluate the efficacy and safety ofS. cerevisiae CNCM I-3856 in the treatment of IBS.MethodsThis was a prospective, randomized, placebo-controlled study. One hundred newly diagnosed subjects with IBS were subgrouped into IBS-D, IBS-C, and IBS-M and then randomized to theS. cerevisiae...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Conclusion: Functional diarrhea was associated with hemodynamic indices of sympathetic activation, supporting a possible role of the autonomic nervous system in diarrhea. PMID: 31791149 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Objectives: Limited research suggests commonalities between urological chronic pelvic pain syndromes (UCPPS) and other nonurological chronic overlapping pain conditions (COPCs) including fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome. The goal of this case-control study was to examine similarities and differences between UCPPS and these other COPCs. Materials and Methods: As part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research (MAPP) Network, we examined 1039 individuals with UCPPS (n=424), nonurological COPCs (n=200), and healthy controls (HCs; n=415). Validated st...
Source: The Clinical Journal of Pain - Category: Anesthesiology Tags: Original Articles Source Type: research
Irritable bowel syndrome (IBS) is prevalent in patients with morbid obesity. After Roux-en-Y gastric bypass (RYGB) chronic abdominal pain is common, however the etiology is largely unknown. We aimed to study t...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Research article Source Type: research
In conclusion, the ISQ has appropriate face, content, and construct validity and is a reliable, stable and valid method to assess the past 12 month’s perceived immune status.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Abstract BACKGROUND: Fecal metabolites are associated with gut visceral sensitivity, mucosal immune function and intestinal barrier function, all of which have critical roles in the pathogenesis of irritable bowel syndrome (IBS). However, the metabolic profile and pathophysiology of IBS are still unclear. We hypothesized that altered profiles of fecal metabolites might be involved in the pathogenesis of IBS with predominant diarrhea (IBS-D). AIM: To investigate the fecal metabolite composition and the role of metabolites in IBS-D pathophysiology. METHODS: Thirty IBS-D patients and 15 age- and sex-matched...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Chronic pelvic pain (CPP) is a frequent health problem in women during childbearing age. Etiology of CPP includes irritable bowel syndrome, endometriosis, adenomyosis, pelvic congestion syndrome, urological disorders and psychosocial issues.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Tags: IMAGES IN Gynecological Surgery Source Type: research
Conclusions: EA treatment can decrease the expression of hypothalamic CRF and CRF-R1, relieve anxiety and depression, meanwhile reduce the expression of CRF-R1 in the gastrointestinal mucosa, increase ZO-1 expression, and adjust tight junctions (TJs) to repair the intestinal mucosal barrier. The above roles suggest that EA may play a dual role in alleviating the gastrointestinal and psychological symptoms of IBS, suggesting a potentially dual therapeutic role for EA in regulating disorders of gut-brain interaction in IBS rats. PMID: 31737064 [PubMed]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Many factors can cause colon pain, including constipation, diarrhea, irritable bowel syndrome, and colorectal cancer. Learn more about the causes of colon pain and their treatment options here.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: GastroIntestinal / Gastroenterology Source Type: news
More News: Diets | Gastroenterology | Irritable Bowel Syndrome | Lactose | Nutrition | Pain