Cancers, Vol. 11, Pages 1764: Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide

Cancers, Vol. 11, Pages 1764: Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide Cancers doi: 10.3390/cancers11111764 Authors: Anastasios I. Birmpilis Chrysoula-Evangelia Karachaliou Pinelopi Samara Kyriaki Ioannou Platon Selemenakis Ioannis V. Kostopoulos Nadia Kavrochorianou Hubert Kalbacher Evangelia Livaniou Sylva Haralambous Athanasios Kotsinas Farzin Farzaneh Ioannis P. Trougakos Wolfgang Voelter Meletios-Athanasios Dimopoulos Aristotelis Bamias Ourania Tsitsilonis Prothymosin α (proTα) and its C-terminal decapeptide proTα(100–109) were shown to pleiotropically enhance innate and adaptive immune responses. Their activities have been broadly studied in vitro, focusing primarily on the restoration of the deficient immunoreactivity of cancer patients’ leukocytes. Previously, we showed that proTα and proTα(100–109) act as danger-associated molecular patterns (DAMPs), ligate Toll-like receptor-4, signal through TRIF- and MyD88-dependent pathways, promote the maturation of dendritic cells and elicit T-helper type 1 (Th1) immune responses in vitro, leading to the optimal priming of tumor antigen-reactive T-cell functions. Herein, we assessed their activity in a preclinical melanoma model. Immunocompetent mice bearing B16.F1 tumors were treated with two cycles of pro...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research