Cancers, Vol. 11, Pages 1764: Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide
Cancers, Vol. 11, Pages 1764: Antitumor Reactive T-Cell Responses Are Enhanced In Vivo by DAMP Prothymosin Alpha and Its C-Terminal Decapeptide
Cancers doi: 10.3390/cancers11111764
Authors:
Anastasios I. Birmpilis
Chrysoula-Evangelia Karachaliou
Pinelopi Samara
Kyriaki Ioannou
Platon Selemenakis
Ioannis V. Kostopoulos
Nadia Kavrochorianou
Hubert Kalbacher
Evangelia Livaniou
Sylva Haralambous
Athanasios Kotsinas
Farzin Farzaneh
Ioannis P. Trougakos
Wolfgang Voelter
Meletios-Athanasios Dimopoulos
Aristotelis Bamias
Ourania Tsitsilonis
Prothymosin α (proTα) and its C-terminal decapeptide proTα(100–109) were shown to pleiotropically enhance innate and adaptive immune responses. Their activities have been broadly studied in vitro, focusing primarily on the restoration of the deficient immunoreactivity of cancer patients’ leukocytes. Previously, we showed that proTα and proTα(100–109) act as danger-associated molecular patterns (DAMPs), ligate Toll-like receptor-4, signal through TRIF- and MyD88-dependent pathways, promote the maturation of dendritic cells and elicit T-helper type 1 (Th1) immune responses in vitro, leading to the optimal priming of tumor antigen-reactive T-cell functions. Herein, we assessed their activity in a preclinical melanoma model. Immunocompetent mice bearing B16.F1 tumors were treated with two cycles of pro...
Source: Cancers - Category: Cancer & Oncology Authors: Anastasios I. Birmpilis Chrysoula-Evangelia Karachaliou Pinelopi Samara Kyriaki Ioannou Platon Selemenakis Ioannis V. Kostopoulos Nadia Kavrochorianou Hubert Kalbacher Evangelia Livaniou Sylva Haralambous Athanasios Kotsinas Farzin Farzaneh Ioannis P. Tro Tags: Article Source Type: research