Long-term clinical outcomes of 538 prostate carcinoma patients treated with combination high-dose-rate brachytherapy and external beam radiotherapy

ConclusionCombined HDR-B/EBRT for the treatment of clinically localized prostate cancer provides superb clinical outcomes with excellent 5-year bRFS, dMFS, OS, and late GI/GU toxicity rates.
Source: Journal of Radiation Oncology - Category: Cancer & Oncology Source Type: research

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Conditions:   Metastatic Prostate Adenocarcinoma;   Prostate Adenocarcinoma;   Recurrent Prostate Carcinoma;   Stage IV Prostate Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8 Interventions:   Radiation: Intensity-Modulated Radiation Therapy;   Radiation: Proton Beam Radiation Therapy;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration Sponsors:   Mayo...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
68Ga-PSMA PET/CT has become a well-established imaging modality to detect prostate cancer (PCa) metastases in biochemical recurrence. Despite its claimed specificity for PCa, 68Ga-PSMA uptake in tissues unrelated to PCa, particularly in the neovascular tissue of other cancers, has been reported in numerous studies. A 73-year-old man underwent 68Ga-PSMA PET/CT for biochemical recurrence of PCa 7 years after radical prostatectomy. The 68Ga-PSMA PET/CT showed 1 lesion with PSMA uptake in the distal left ureter. Histology revealed a low-grade noninvasive papillary urothelial carcinoma. By immunohistochemistry, PSMA expression ...
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
CONCLUSION: Primary Signet ring cell carcinoma of the prostate is a rare and aggressive histological variant of adenocarcinomas of the prostate. Treatment is the same as classical adenocarcinoma with an emphasis on aggressive multimodal treatment. PMID: 31797810 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research
We present a case of de novo adenosquamous carcinoma of the prostate treated with a multimodal approach including surgery, androgen-deprivation therapy, chemotherapy, and radiation.
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
CONCLUSIONS: The combination of BCL2 and Wee1 inhibition presents a novel therapeutic strategy for the treatment of SCNPC. PMID: 31806643 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Robot-assisted laparoscopic radical prostatectomy (RALRP) is one of the treatment options for localized prostate cancer, with an excellent disease control rate. However, these patients can experience late disease recurrence with metastatic dissemination. Peritoneal metastases are an uncommon recurrence site. Here, we discuss three cases of peritoneal metastases following RALRP and the mechanisms of peritoneal invasion. Through a literature review and our case reports, we postulate the existence of two distinct mechanisms of peritoneal invasion: one being iatrogenic, following a laparoscopic surgery with a well differentiat...
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
In this study, biopsy images are used for histological grading and the analysis of benign and malignant prostate tissues. The following PCa grades are analysed in the present study: benign, grade 3, grade 4, and grade 5. Biopsy imaging has become increasingly important for the clinical assessment of PCa. In order to analyse and classify the histological grades of prostate carcinomas, pixel-based colour moment descriptor (PCMD) and gray-level co-occurrence matrix (GLCM) methods were used to extract the most significant features for multilayer perceptron (MLP) neural network classification. Haar wavelet transformation was ca...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Abstract CLINICAL/METHODICAL ISSUE: In view of the diagnostic complexity and the large number of examinations, modern radiology is challenged to identify clinically significant prostate cancer (PCa) with high sensitivity and specificity. Meanwhile overdiagnosis and overtreatment of clinically nonsignificant carcinomas need to be avoided. STANDARD RADIOLOGICAL METHODS: Increasingly, international guidelines recommend multiparametric magnetic resonance imaging (mpMRI) as first-line investigation in patients with suspected PCa. METHODICAL INNOVATIONS: Image interpretation according to the PI-RADS criteria i...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research
Antioxidation and Antiapoptosis Characteristics of Heme Oxygenase-1 Enhance Tumorigenesis of Human Prostate Carcinoma Cells. Transl Oncol. 2019 Dec 03;13(1):102-112 Authors: Chiang KC, Tsui KH, Lin YH, Hou CP, Chang KS, Tsai HH, Shin YS, Chen CC, Feng TH, Juang HH Abstract Heme oxygenase-1 (HO-1) has antiinflammatory and antioxidant properties and is deemed as a tissue protector. However, effects of HO-1 in prostate cancer remain in controversy. We evaluated the role of HO-1 in prostate carcinoma in vitro and in vivo. Overexpression of HO-1 did not affect prostate cell proliferation in the n...
Source: Translational Oncology - Category: Cancer & Oncology Authors: Tags: Transl Oncol Source Type: research
Conclusions223RaCl2 has demonstrated “proof of concept” for use of TAT in cancer in clinical practice. The efficacy and safety of223RaCl2 monotherapy have been demonstrated in mCRPC, and223RaCl2 combination therapies are under investigation in various tumours. TAT has broad applicability across tumour types.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
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