Association between infliximab concentrations and clinical response in psoriasis: a prospective cohort study.

CONCLUSION: IFX Cmin significantly influences PASI 90/100 response rates. IFX Cmin were significantly associated with ATI and BMI. The observed inter-individual variability in IFX Cmin supports the need for IFX drug monitoring. PMID: 31696747 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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Publication date: Available online 10 December 2019Source: Pharmacology &TherapeuticsAuthor(s): Lingling Zhang, Wei WeiAbstractAs a Traditional Chinese Medicine, Paeonia lactiflora Pallas has been used to treat pain, inflammation and immune disorders for more than 1000 years in China. Total glycoside of paeony (TGP) is extracted from the dried root of Paeonia lactiflora Pallas. Paeoniflorin (Pae) is the major active component of TGP. Our research group has done a lot of work in the pharmacological mechanisms of Pae and found that Pae possessed extensive anti-inflammatory and immune regulatory effects. Pae could inhib...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
In the 1990s patients with psoriasis were suffering with few options. To complement their treatment, we started a psoriasis support group, engaging a psychologist, Dr Stephen Rapp, to support our efforts. Dr Rapp was intrigued by the enormous impact that he saw psoriasis having on our patients. Together, we embarked on a quantitative study of that impact. Dr Rapp brought to this project his expertise in formal quality of life assessment; at the time, such patient-reported outcomes were just beginning to be used in dermatology.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Celebrating 40 years in publication Source Type: research
Conclusion: Increased IFN-κ in psoriasis may be caused by injured cells-released nucleic acids, increased IFN-γ and self-activation. Its enhancement may contribute to the etiology of the disease by enhancing TNFA and IL17A gene expression. PMID: 31819584 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Authors: Grajdeanu IA, Statescu L, Vata D, Popescu IA, Porumb-Andrese E, Patrascu AI, Taranu T, Crisan M, Solovastru LG Abstract Plaque psoriasis is a chronic, immune-mediated disease, which has a multifactorial etiopathogenesis. Practical non-invasive techniques to monitor plaque psoriasis progression and treatment are necessary. Imaging techniques available for psoriasis assessment may vary in terms of resolution, depth of penetration and visual representation. This review summarizes the current developments in the field of psoriasis non-invasive imaging techniques, such as dermoscopy, conventional ultrasound and...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
WEDNESDAY, Dec. 11, 2019 -- Rates of type 2 diabetes may be higher among patients with psoriasis, according to a study published online Dec. 3 in the Journal of the European Academy of Dermatology and Venereology. Wiebke Sondermann, Dr. Med., from...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Gene Variant in the NF-κB Pathway Inhibitor NFKBIA Distinguishes Patients with Psoriatic Arthritis within the Spectrum of Psoriatic Disease. Biomed Res Int. 2019;2019:1030256 Authors: Coto-Segura P, Coto E, González-Lara L, Alonso B, Gómez J, Cuesta-Llavona E, Queiro R Abstract Background and Aims: The NF-κB pathway has been implicated in the genetic aetiology of psoriatic disease. However, since most patients with arthritis have psoriasis, discerning the genetic contributions to both aspects of psoriatic disease is not easy. Our aim was to study the association of common pol...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Epigenetic regulation has profound influence on stem cell fate during normal development in maintenance of physiologic tissue homeostasis. Here we report diminished ten-eleven translocation (TET) methylcytosine dioxygenase expression and loss of the DNA hydroxymethylation mark, 5-hydroxymethylcytosine (5-hmC), in keratinocyte stem cells (KSCs) and transit-amplifying cells (TACs) in human psoriasis and in imiquimod-induced murine psoriasis. Loss of 5-hmC was associated with dysregulated KSC kinetics, resulting in accumulation of nestin and FABP5-expressing TACs to produce classic psoriatic epidermal architecture.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
Human skin harbors a diverse group of microorganism that form complex communities and involve in a variety of complex molecular and cellular processes inside and outside the skin [1], and even influence gene expression in skin [2]. These microbiota interact directly with skin cells and play a central role in skin physiology and disease [3]. Many of evidence suggest a role for microorganisms in noninfectious skin diseases, such as atopic dermatitis (AD), rosacea, psoriasis, and acne [4]. However, the origin of many skin diseases is multifactorial and in some cases, such as the sensitive skin syndrome (SS), the role of micro...
Source: Journal of Dermatological Science - Category: Dermatology Authors: Source Type: research
Authors: Sun L, Liu W, Zhang LJ Abstract As the key defense molecules originally identified in Drosophila, Toll-like receptor (TLR) superfamily members play a fundamental role in detecting invading pathogens or damage and initiating the innate immune system of mammalian cells. The skin, the largest organ of the human body, protects the human body by providing a critical physical and immunological active multilayered barrier against invading pathogens and environmental factors. At the first line of defense, the skin is constantly exposed to pathogen-associated molecular patterns (PAMPs) and damage-associated molecul...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
This review examined the impact of weight loss on pre-existing psoriasis or psoriatic arthritis. Might losing weight prevent the onset of psoriasis in obese individuals?The British Journal of Dermatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news
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