Review of treatments for generalized pustular psoriasis manuscript.

Conclusions: This review highlights the research in support of common treatments of GPP, including classically used medications and newer monoclonal antibodies, and addresses the continued need for high quality studies regarding treatments for this condition. PMID: 31697211 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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This study aimed to investigate the potential regulatory effect of tacrolimus on TNF- α/ IL-17A-costimulated human keratinocytes in the mimic psoriatic microenvironment. The cultured normal human keratinocytes (NHKs) were divided into the following groups: control, TNF-α/IL-17A, tacrolimus, and TNF-α/IL-17A + tacrolimus. Cultured cells and supernatant were collected after 24  h, and then real-time quantitative PCR, western blot, and ELISA analysis were performed. Foreskin tissues were treated by using TNF-α, IL-17A, and tacrolimus 0.03% ointment and then cultured for 24 h, an...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
Authors: Dalmády S, Kemény L, Antal M, Gyulai R Abstract Introduction: Psoriasis is a chronic autoimmune skin disease with strong genetic background and environmental triggers. Patients with psoriasis and psoriatic arthritis are at greater risk of developing other chronic and potentially severe comorbidities, such as psoriatic arthritis, hyperlipidemia, type 2 diabetes mellitus, obesity, metabolic syndrome, cardiovascular diseases or depression. Recently, accumulating epidemiologic, genetic and pathogenetic evidence indicates that psoriasis is also associated with periodontitis, a chronic progressive ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Publication date: Available online 11 December 2019Source: Journal of ColoproctologyAuthor(s): José Antonio Dias da Cunha e Silva, Laís Lima, Lygia De George, Thalita Araújo Sant’Ana, Marcus ValadãoAbstractThe Buschke-Lowenstein tumor, known as the giant condyloma acuminatum, is a rare lesion of the anorectal and PerianaL region; it is sexually transmitted and associated with human papilloma virus, types 6 and 11. Histologically, it is a benign tumor, but it can reach big proportions and may behave aggressively. The purpose of this study is to report the case of a patient diagnosed with HI...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Publication date: Available online 10 December 2019Source: Pharmacology &TherapeuticsAuthor(s): Lingling Zhang, Wei WeiAbstractAs a Traditional Chinese Medicine, Paeonia lactiflora Pallas has been used to treat pain, inflammation and immune disorders for more than 1000 years in China. Total glycoside of paeony (TGP) is extracted from the dried root of Paeonia lactiflora Pallas. Paeoniflorin (Pae) is the major active component of TGP. Our research group has done a lot of work in the pharmacological mechanisms of Pae and found that Pae possessed extensive anti-inflammatory and immune regulatory effects. Pae could inhib...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
In the 1990s patients with psoriasis were suffering with few options. To complement their treatment, we started a psoriasis support group, engaging a psychologist, Dr Stephen Rapp, to support our efforts. Dr Rapp was intrigued by the enormous impact that he saw psoriasis having on our patients. Together, we embarked on a quantitative study of that impact. Dr Rapp brought to this project his expertise in formal quality of life assessment; at the time, such patient-reported outcomes were just beginning to be used in dermatology.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Celebrating 40 years in publication Source Type: research
This study aimed at characterizing epidermal alterations in psoriasis at the level of keratinocyte populations. Epidermal cell populations were purified from skin biopsies of psoriasis patients and healthy donors using a novel cell type-specific approach. Molecular characterization of the transit-amplifying cells (TAC), the key players of epidermal renewal, was performed using immunocytofluorescence-technique and integrated multiscale-omics analyses. Already TAC from non-lesional psoriatic skin showed altered methylation and differential expression in 1.7% and 1.0% of all protein-coding genes, respectively. In psoriatic le...
Source: Journal of Molecular Medicine - Category: Molecular Biology Source Type: research
Itolizumab, a first-in-class humanized anti-CD6 monoclonal antibody, is developed by Biocon and launched in 2013 in India under the brand name ALZUMAb to treat moderate to severe plaque psoriasis, a skin disease.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
Conclusion: Increased IFN-κ in psoriasis may be caused by injured cells-released nucleic acids, increased IFN-γ and self-activation. Its enhancement may contribute to the etiology of the disease by enhancing TNFA and IL17A gene expression. PMID: 31819584 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Authors: Grajdeanu IA, Statescu L, Vata D, Popescu IA, Porumb-Andrese E, Patrascu AI, Taranu T, Crisan M, Solovastru LG Abstract Plaque psoriasis is a chronic, immune-mediated disease, which has a multifactorial etiopathogenesis. Practical non-invasive techniques to monitor plaque psoriasis progression and treatment are necessary. Imaging techniques available for psoriasis assessment may vary in terms of resolution, depth of penetration and visual representation. This review summarizes the current developments in the field of psoriasis non-invasive imaging techniques, such as dermoscopy, conventional ultrasound and...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
WEDNESDAY, Dec. 11, 2019 -- Rates of type 2 diabetes may be higher among patients with psoriasis, according to a study published online Dec. 3 in the Journal of the European Academy of Dermatology and Venereology. Wiebke Sondermann, Dr. Med., from...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
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