Altered immune system in offspring of rat maternal vertical sleeve gastrectomy.

Altered immune system in offspring of rat maternal vertical sleeve gastrectomy. Am J Physiol Regul Integr Comp Physiol. 2019 Nov 06;: Authors: Spann RA, Taylor EB, Welch BA, Grayson BE Abstract Obesity in women results in reduced fertility and increased complications during pregnancy. Vertical sleeve gastrectomy (VSG) effectively reduces weight, type-2 diabetes and dyslipidemia, but is also associated with preterm and small-for-gestational age births. The mechanism by which VSG impacts fetal development remains unknown. Here we hypothesize that previously reported immune changes during rat VSG pregnancy are reflected long-term in the immune system of the offspring. Offspring of VSG and Sham dams were evaluated at postnatal day (PND) 21 and PND60. At PND21, VSG pups have lower numbers of circulating B lymphocytes compared to Sham pups (P
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

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