HPV and cancer: The underappreciated connection
Did you know that a viral infection can lead to a number of different types of cancer? If that comes as a surprise to you, you’re not alone. In fact, according to a new study, many people have no idea that a common viral infection called human papilloma virus (HPV) can cause cancer of the genitals, anus, mouth, and throat, as well as cervical cancer. Viral infections and cancer The connection between certain viral infections and cancer has been recognized for many years. Some of the most well-established examples include hepatitis C, human immunodeficiency virus (HIV), and human papillomavirus (HPV). One thing these viruses have in common is that the immune system may have trouble fighting them off, allowing an infection to become chronic. HPV and cancer According to the CDC, HPV causes about 44,000 cancers in men and women each year in the US. The connection between HPV and cancer is particularly important to know about, because there is an approved vaccine to prevent many strains of HPV infection most closely linked to cancer. And it works: since the approval of the initial vaccine in 2006, rates of HPV infection and cervical cancer have dropped significantly. Unfortunately, far too few kids and young adults receive the vaccine. Perhaps a lack of awareness of the link to different cancers is one reason for the low numbers, even though the connection has been known for many years. Besides cervical cancer, HPV can also cause cancers of the mouth and throat penis anus v...
Authors: Chang C, Wu H, Lu Q Abstract Food allergy is a global health problem, particularly in developed countries. It is mainly mediated by Th2 cell and IgE produced by B cells. While the pathogenesis of IgE-mediated food allergy is quite straightforward, the factors that lead to the development of food allergies at any age in children and adults are unclear. Recent studies have revealed that genetics, epigenetics, and environmental exposures contribute to the development of atopy. In this chapter, we discuss the interplay between these three key elements, reveal how epigenetic modifications may mediate genetic su...
Authors: Ceribelli A, Selmi C Abstract Genomic predisposition fails to fully explain the onset of complex diseases, which is well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodeling, and non-coding RNA, are the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory diseases. Autoimmune diseases now include almost 100 conditions and are estimated to cumulatively affect up to 5% of the world population with a healthcare expenditure superior to cancer wor...
Authors: Zhang L, Lu Q, Chang C Abstract Epigenetic mechanisms, which include DNA methylation, histone modification, and microRNA (miRNA), can produce heritable phenotypic changes without a change in DNA sequence. Disruption of gene expression patterns which are governed by epigenetics can result in autoimmune diseases, cancers, and various other maladies. Mechanisms of epigenetics include DNA methylation (and demethylation), histone modifications, and non-coding RNAs such as microRNAs. Compared to numerous studies that have focused on the field of genetics, research on epigenetics is fairly recent. In contrast to ...
[The Conversation Africa] Researchers are racing against time to find ways to treat and prevent COVID-19. There is currently no treatment for the disease, and the World Health Organisation has created Solidarity, a global clinical trial which is testing four drugs as possible treatment. There are also more than 90 vaccine trials being undertaken worldwide, but it may take more than a year before a vaccine is developed. And there is currently a global shortage of COVID-19 testing kits.
CONCLUSION: Radiological imaging is essential for the management of patients affected by lung cancer. PMID: 32445458 [PubMed - as supplied by publisher]
Condition: Non Small Cell Lung Cancer Intervention: Drug: TQ-B3139 Sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Not yet recruiting
Conditions: ICC; Metastatic Cancer Interventions: Drug: Folfirinox; Drug: Sintilimab Sponsor: Sun Yat-sen University Recruiting
Condition: Breast Cancer Invasive Interventions: Drug: Pyrotinib; Drug: Trastuzumab; Drug: Pertuzumab; Drug: Nab-paclitaxel; Drug: EC chemotherapy; Drug: Physician's choice; Drug: T-DM1; Procedure: Surgery Sponsors: Shanghai Jiao Tong University School of Medicine; Jiangsu HengRui Medicine Co., Ltd. Not yet recruiting
Conditions: Neuroendocrine Tumor; Anaplastic Thyroid Cancer; Adenocarcinoma; Pheochromocytoma; Paraganglioma Intervention: Drug: Cabozantinib 40 mg Sponsors: Grupo Espanol de Tumores Neuroendocrinos; Ipsen; Roche Pharma AG Not yet recruiting
Conditions: Solid Tumor; Gastric Cancer; Pancreatic Adenocarcinoma Intervention: Drug: AB011 Injection Sponsors: Carsgen Therapeutics, Ltd.; Shanghai East Hospital Not yet recruiting
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