Nearly 600 new flu cases, two deaths in last week, CDC says

Weekly CDC estimates indicate 582 new cases of influenza, with Louisiana and Puerto Rico still seeing brunt of activity, the agency reported on Friday.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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Review in-depth clinical information, latest medical news, and guidelines on influenza virus and H1N1. Review management of flu symptoms using flu treatment for swine flu, bird flu, and other types of influenza.
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Resource Center Source Type: news
Publication date: 12 November 2019Source: Cell Reports, Volume 29, Issue 7Author(s): Erika Bongen, Haley Lucian, Avani Khatri, Gabriela K. Fragiadakis, Zachary B. Bjornson, Garry P. Nolan, Paul J. Utz, Purvesh KhatriSummarySex differences in autoimmunity and infection suggest that a better understanding of molecular sex differences will improve the diagnosis and treatment of immune-related disease. We identified 144 differentially expressed genes, referred to as immune sex expression signature (iSEXS), between human males and females using an integrated multi-cohort analysis of blood transcriptome profiles from six discove...
Source: Cell Reports - Category: Cytology Source Type: research
Conclusion: Livin promotes autophagy in colon cancer cells via regulating the phosphorylation of H2A.XY142.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Diabetes mellitus is a growing problem worldwide; however, only 23% of low-income countries have access to insulin, and ironically it costs higher in such countries than high-income ones. Therefore, new strategies for insulin and insulin analogs production are urgently required to improve low-cost access to therapeutic products, so as to contain the diabetes epidemic. SCI-57 is an insulin analog with a greater affinity for the insulin receptor and lower thermal degradation than native insulin. It also shows native mitogenicity and insulin-like biological activity. In this work, SCI-57 was transiently expressed in the Nicot...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conditions:   Flu, Human;   Influenza, Human Intervention:   Behavioral: Video about safety and effectiveness of adult seasonal flu vaccination Sponsors:   Harvard University;   Stanford University;   Massachusetts Institute of Technology Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThese results suggested that IFN-γ plays an important role in acute lung injury induced by severe influenza A(H1N1)pdm09 infection, and monoclonal antibodies against IFN-γ could be useful as a potential therapeutic remedy for future influenza pandemics.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
Current challenges: from the path of "original antigenic sin" towards the development of universal flu vaccines. Int Rev Immunol. 2019 Nov 09;:1-16 Authors: Biswas A, Chakrabarti AK, Dutta S Abstract Annual flu led by influenza viruses is contemplated to be one of the foremost global health challenges due to its rapid spread leading to the life-threatening epidemic or pandemic. An enormous number of people die due to flu and its associated intricacies every year. Annual vaccination is considered to be the gold standard strategy to protect the individual from acquiring infection and further de...
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
A recent study in this journal reported the cross-species transmission of a novel swine H3N2 influenza A virus (IAV) to humans and suggested a heavy threat from the H3N2 IAVs (1). Vaccination remains the primary option for the control of influenza, but the protective efficiency of seasonal vaccines against H3N2 IAVs are suboptimal. Recent human H3N2 IAVs have shown poor growth in MDCK cells and eggs due to their low receptor binding affinities. A high yield strain is required for the vaccine manufacture, however, mutations of vaccine seeds during egg adaptation has reported to reduce the vaccine effectiveness (2).
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Current influenza vaccines manufactured using eggs have considerable limitations, both in terms of scale up production and the potential impact passaging through eggs can have on the antigenicity of the vaccine virus strains. Alternative methods of manufacture are required, particularly in the context of an emerging pandemic strain. Here we explore the production of recombinant influenza haemagglutinin using the ciliated protozoan Tetrahymena thermophila. For the first time we were able to produce haemagglutinin from both seasonal influenza A and B strains. This ciliate derived material was immunogenic, inducing an antibod...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
TUESDAY, Nov. 12, 2019 -- About one in three individuals with atherosclerotic cardiovascular disease (ASCVD) did not receive an influenza vaccination in the past year, according to a study presented at the annual meeting of the American Heart...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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