Health Tip: Understanding Toenail Fungus

-- A toenail fungal infection typically occurs beneath the surface of the nail, says the American Podiatric Medical Association. Damp areas from swimming pools to locker rooms heighten the risk of getting a toenail fungal infection. Typically after...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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We describe a homozygous mutation in NFKB1 (G960R) that interrupts T and B cell maturation and is associated with severe viral, microbial and fungal infections during infancy.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions: Although morphological and biochemical tests are still used, they are associated with high-throughput sequencing techniques, due to their accuracy and time saving for profiling the predominant species in oral mycobiome. PMID: 32944157 [PubMed]
Source: Journal of Oral Microbiology - Category: Microbiology Tags: J Oral Microbiol Source Type: research
Study and Development of an Anthroposophical Formula Based on Phosphorus and Formica rufa for Onychomycosis´s Treatment. Recent Pat Drug Deliv Formul. 2020 Sep 17;: Authors: Rodrigues AM, de Figueiredo SM, La Santrer EFR, Assunção CB, de Abreu ASG, Johann S, Caligiorne RB Abstract Onychomycosis is a fungal infection of the nail plate or nail bed that leads to gradual destruction of the nail. The main difficulties in the treatment of onychomycosis refer to the duration of treatments and their side effects. Thus, it becomes relevant to look for new therapeutic alternatives in the trea...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research
Fine needle aspiration cytology (FNAC) with rapid on-site evaluation has a great potential for the diagnosis of fungal lesions and other opportunistic infections. Fungal infections have been in increasing tren...
Source: Diagnostic Pathology - Category: Pathology Authors: Tags: Case Report Source Type: research
Authors: Höft MA, Hoving JC, Brown GD Abstract We are all exposed to fungal organisms daily, and although many of these organisms are not harmful, billions of people a year contract a fungal infection. Most of these infections are not fatal and can be cleared by the host immune response. However, due to an increase in high-risk populations, the global fungal burden has increased, with more than 1.5 million deaths per year caused by invasive fungal infections. The fungal cell wall is an important surface for interacting with the host immune system as it contains pathogen-associated molecular patterns (PAMPs) wh...
Source: Current Topics in Microbiology and Immunology - Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research
Youl Cho Tabebuia impetiginosa, a plant native to the Amazon rainforest and other parts of Latin America, is traditionally used for treating fever, malaria, bacterial and fungal infections, and skin diseases. Additionally, several categories of phytochemicals and extracts isolated from T. impetiginosa have been studied via various models and displayed pharmacological activities. This review aims to uncover and summarize the research concerning T. impetiginosa, particularly its traditional uses, phytochemistry, and immunopharmacological activity, as well as to provide guidance for future research. A comprehensive searc...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
a MDL Abstract Fungi stand out as primary pathogens present in healthcare-acquired infections, presenting an increased number of cases even using appropriate antifungal therapy. Candida spp. is a predominant microorganism among several fungal pathogens present in the healthcare setting. Candidemia and candidiasis are fungal infections responsible for high morbidity and mortality among ill patients in hospitals. It is noticeable that prolonged hospital stays lead to a higher economic impact and increased risk for developing secondary fungal or even bacterial infections. New fast and sensitive approaches for the det...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
The purpose of this review is to describe antifungal therapeutic candidates in preclinical and clinical development derived from, or directly influenced by, the immune system, with a specific focus on antimicrobial peptides (AMP). Although the focus of this review is AMP with direct antimicrobial effects on fungi, we will also discuss compounds with direct antifungal activity, including monoclonal antibodies (mAb), as well as immunomodulatory molecules that can enhance the immune response to fungal infection, including immunomodulatory AMP, vaccines, checkpoint inhibitors, interferon and colony stimulating factors as well ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
ConclusionsThe Karius Test may offer a valuable and timely option for the diagnosis of invasive fungal infection through its non-invasive approach and subsequent cost savings.
Source: Applied Health Economics and Health Policy - Category: Health Management Source Type: research
In this study, the antifungal effects of both cells and cell-free supernatants (CFSs) of L. acidophilus and L. plantarum were investigated against different oral Candida species by co-aggregation, agar overlay interference and broth microdilution assays, respectively. Our results showed that the highest co-aggregation ratio of the two tested Lactic acid bacteria (LAB) was observed for C. krusei. Both L. acidophilus and L. plantarum at cell concentrations 1010 to 102 cfu/ml were able to inhibit the growth of most of the oral Candida species, except for C. albicans, and to some C. krusei. In this study, MIC and MFC values fo...
Source: Journal of Oral Microbiology - Category: Microbiology Tags: J Oral Microbiol Source Type: research
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