New generation of oral mucosal vaccines targeting dendritic cells.

New generation of oral mucosal vaccines targeting dendritic cells.
Curr Opin Chem Biol. 2013 Jul 5;
Authors: Owen JL, Sahay B, Mohamadzadeh M
Abstract
As most infectious organisms gain entry at mucosal surfaces, there is a great deal of interest in developing vaccines that elicit effective mucosal immune responses against pathogen challenge. Targeted vaccination is one of the most effective methods available to prevent and control infectious diseases. Mucosal vaccines can offer lower costs, better accessibility, needle free delivery, and a higher capacity for mass immunizations during pandemics. Both local mucosal immunity and robust systemic responses can be achieved through mucosal vaccination. Recent progress in understanding the molecular and cellular components of the mucosal immune system have allowed for the development of a novel mucosal vaccine platform utilizing specific dendritic cell-targeting peptides and orally administered lactobacilli to elicit efficient antigen specific immune responses against infections, including Bacillus anthracis in experimental models of disease.
PMID: 23835515 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - July 5, 2013 Category: Biochemistry Authors: Owen JL, Sahay B, Mohamadzadeh M Tags: Curr Opin Chem Biol Source Type: research