New generation of oral mucosal vaccines targeting dendritic cells.

New generation of oral mucosal vaccines targeting dendritic cells. Curr Opin Chem Biol. 2013 Jul 5; Authors: Owen JL, Sahay B, Mohamadzadeh M Abstract As most infectious organisms gain entry at mucosal surfaces, there is a great deal of interest in developing vaccines that elicit effective mucosal immune responses against pathogen challenge. Targeted vaccination is one of the most effective methods available to prevent and control infectious diseases. Mucosal vaccines can offer lower costs, better accessibility, needle free delivery, and a higher capacity for mass immunizations during pandemics. Both local mucosal immunity and robust systemic responses can be achieved through mucosal vaccination. Recent progress in understanding the molecular and cellular components of the mucosal immune system have allowed for the development of a novel mucosal vaccine platform utilizing specific dendritic cell-targeting peptides and orally administered lactobacilli to elicit efficient antigen specific immune responses against infections, including Bacillus anthracis in experimental models of disease. PMID: 23835515 [PubMed - as supplied by publisher]
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Tags: Curr Opin Chem Biol Source Type: research

Related Links:

(Natural News) As the totally discredited mainstream media continues to pretend that the coronavirus pandemic isn’t real, the truth is starting to emerge from establishment scientists who are warning the world that this outbreak cannot be contained. One of those individuals is Nancy Messonnier. She works for the CDC and previously served as an “Epidemic...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Publication date: Available online 23 October 2018Source: EpidemicsAuthor(s): Martha I. Nelson, James O. Lloyd-Smith, Lone Simonsen, Andrew Rambaut, Edward C. Holmes, Gerardo Chowell, Mark A. Miller, David J. Spiro, Bryan Grenfell, Cécile ViboudAbstractDue to a combination of ecological, political, and demographic factors, the emergence of novel pathogens has been increasingly observed in animals and humans in recent decades. Enhancing global capacity to study and interpret infectious disease surveillance data, and to develop data-driven computational models to guide policy, represents one of the most cost-effective...
Source: Epidemics - Category: Epidemiology Source Type: research
Conclusions Using a systematic evidence base and consensus development process among stakeholders within and outside VA, we report on the first national VA comprehensive emergency management program evaluation and research agenda. VA provides a unique national laboratory for the conduct of high quality research that will improve VA’s and our Nation’s emergency medical and public health preparedness and the role of health delivery systems in that endeavor. To effectively foster the conduct and expansion of emergency management evaluation and research within VA, the consensus was that VA needs to build program ev...
Source: PLOS Currents Disasters - Category: Global & Universal Authors: Source Type: research
Editor’s Note: This post reflects on a speech on pandemic preparedness Dr. Fauci gave on January 10, 2017 in Washington, DC, hosted by  The Center for Global Health Science and Security at Georgetown University Medical Center, the Harvard Global Health Institute, and Health Affairs. One of the most important challenges facing the new Administration is preparedness for the pandemic outbreak of an infectious disease. Infectious diseases will continue to pose a significant threat to public health and the economies of countries worldwide. The U.S. government will need to continue its investment to combat these ...
Source: Health Affairs Blog - Category: Health Management Authors: Tags: Featured Global Health Policy Ebola HIV/AIDS NIH pandemic preparedness Zika Source Type: blogs
This reporting is brought to you by HuffPost’s health and science platform, The Scope. Like us on Facebook and Twitter and tell us your story: scopestories@huffingtonpost.com.  function onPlayerReadyVidible(e){'undefined'!=typeof HPTrack&&HPTrack.Vid.Vidible_track(e)}!function(e,i){if(e.vdb_Player){if('object'==typeof commercial_video){var a='',o='m.fwsitesection='+commercial_video.site_and_category;if(a+=o,commercial_video['package']){var c='&m.fwkeyvalues=sponsorship%3D'+commercial_video['package'];a+=c}e.setAttribute('vdb_params',a)}i(e.vdb_Player)}else{var t=arguments.callee;setTi...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
University of Pittsburgh Medical Center, Center for Health Security. 11/07/2016 This 124-page casebook provides the U.S. Food and Drug Administration (FDA) and other officials who deliver public health information with real world-inspired opportunities for reflective learning on the principles of effective medical countermeasure (MCM) emergency communication. It examines communication dilemmas about MCMs in the context of the 2015-215 Ebola outbreak, 2011 Fukushima nuclear accident, 2009-10 H1N1 influenza pandemic, and 2001 anthrax letter attacks, recommending specific action items for the FDA to help mitigate comparable i...
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: Global & Universal Authors: Source Type: news
This casebook provides the FDA and other officials who deliver public health information with real world inspired opportunities for reflective learning on the principles of effective MCM emergency communication. The casebook critically examined communication dilemmas about MCMs in the context of the 2015-215 Ebola outbreak, the 2011 Fukushima nuclear accident, the 2009-10 H1N1 influenza pandemic, and the 2001 anthrax letter attacks, recommending specific action items for the FDA to help mitigate comparable issues in the future.
Source: PHPartners.org - Category: Global & Universal Source Type: news
ConclusionAlthough less prominently mentioned, neglected zoonotic diseases ranked highly compared to those with epidemic potential suggesting these endemic diseases cause substantial public health burden. The list of priority zoonotic disease is crucial for the targeted allocation of resources and informing disease prevention and control programs for zoonoses in Kenya.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Trust in biologists is in a precarious position. Secrecy, safety breaches and controversial experiments are risking the reputation of biomedical science. Ahead of a key meeting in the USA, Filippa Lentzos and Nicholas Evans outline steps to earn back the trust of citizens.18-months of deliberation on how to regulate research enhancing the transmissibility and virulence of viruses will end when the National Science Advisory Board for Biosecurity (NSABB) meets on 24 May 2016. The modified pathogens created through so-called ‘gain-of-function’ experiments could, if accidentally released from labs or deliberately m...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Science Science policy Flu pandemic Source Type: news
U.S. Senate, Committee on Homeland Security and Governmental Affairs. 04/14/2016This two-hour, 12-minute Congressional hearing covers the perspective of federal agencies on the state of the nation's biodefense, how key federal agencies are fulfilling their responsibilities in this area, and what steps they are taking to improve preparedness and response. Witnesses discuss threats that include bioterrorist agents such as anthrax, smallpox, and botulism; evolving and emerging threats causing substantial regional disruption such as Ebola and Zika; and highly communicable diseases with pandemic potential such as influenza. (Video or Multimedia)
Source: Disaster Lit: Resource Guide for Disaster Medicine and Public Health - Category: Global & Universal Authors: Source Type: news
More News: Anthrax | Anthrax Vaccine | Biochemistry | Biology | Chemistry | Infectious Diseases | Molecular Biology | Pandemics | Vaccines