Leave it to Lefamulin: A Pleuromutilin Treatment Option in Community-Acquired Bacterial Pneumonia

AbstractLefamulin (BC-3781) is the first systemic pleuromutilin antibiotic found to be safe and effective in the treatment of community-acquired bacterial pneumonia (CABP) in humans. This novel antibiotic was developed to combat the increasing incidence of bacterial resistance to current therapies. As the first semisynthetic pleuromutilin for systemic use in humans, lefamulin has demonstrated efficacy against the most common bacteria responsible for CABP, including strains exhibiting resistance to macrolides, fluoroquinolones, tetracyclines, vancomycin, and beta-lactams. In vitro studies have demonstrated efficacy againstStaphylococcus aureus, beta-hemolytic and viridans group streptococci, coagulase-negative staphylococci,Enterococcus faecium, Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Chlamydophila pneumoniae, Legionella pneumophilia, andMoraxella catarrhalis at MIC values lower than those of currently available therapies. Two phase III trials (LEAP-1 and LEAP-2) have demonstrated similar findings, meeting non-inferiority criteria for CABP with a minimal side-effect profile. Pharmacokinetic and pharmacodynamic evaluations have shown sufficient drug levels in plasma, subcutaneous adipose tissue, skeletal muscle, and epithelial lining fluid, warranting further investigation for other clinical uses. Lefamulin was approved by the United States Food and Drug Administration (FDA) on 19 August 2019 for the treatment of CABP.
Source: Drugs - Category: Drugs & Pharmacology Source Type: research

Related Links:

Psychiatric medications are an important part of treatment for many people with mental disorders, such as depression, bipolar disorder, ADHD, schizophrenia, anxiety, and others. They play an important role in helping to alleviate the most serious symptoms, allowing people to better focus on their lives and on other treatment types, such as psychotherapy. Psychiatric medications are an important part of many people’s treatment plans for obtaining the most effective treatment for a mental health concern or mental illness. It’s good to know what drugs are being prescribed most often for mental disorders in the U.S...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Medications Psychiatry psychiatric meds psychiatric prescriptions Source Type: blogs
ConclusionsThis case demonstrates some of the various intraoral and extraoral presentations of HIV infection, including NUP, fingernail hyperpigmentation, cervical lymphadenopathy, molluscum contagiosum, and pseudomembranous candidiasis. Although the patient's chief complaint was painful gingivae, the presence of other lesions led to a suspected, and later confirmed, diagnosis of HIV infection. Therefore, it is important that clinicians know the various manifestations of HIV infection, especially in patients who are undiagnosed. The possibility of undiagnosed HIV infection should be suspected, and a referral for appropriat...
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
A 51-year-old white female patient hospitalized in the intensive care unit because of acute ischemic stroke who needed tracheostomy and vasoactive drugs in high dosage evolved with aspiration pneumonia and septic shock. At 30 days of hospitalization, intraoral examination revealed multiple superficial ulcers on the lips, buccal mucosa, tongue, and mouth floor, circumscribed by erythematous halo and covered by pseudomembrane with severe pain symptomatology and evolution of 15 days. Concomitantly, the patient presented bilateral conjunctivitis with erythema in the sclera and periocular region.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
In the United States, of the approximately 1.1 million people age 13 years and older living with human immunodeficiency virus (HIV) infection, an estimated 162,500 remain undiagnosed. Numerous clinical manifestations of HIV infection have been reported, but these have declined in prevalence since the advent of highly active antiretroviral therapy. Here, we present a case of a previously undiagnosed patient presenting with multiple supportive clinical manifestations that led to a confirmed diagnosis of HIV infection.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
Abstract In recent years, there have been numerous calls by researchers to adopt multi-disciplinary and international perspectives to address the HIV pandemic. Meaningful and prudent public health policy should be based on sound empirical data and research. Henceforth, our study aims to contribute to the current literature by conducting a comprehensive global mapping and determine the landscapes of HIV/AIDS research covering the years between 1983 and 2017. Bibliometric and content analysis was used to describe trends in research productivity, usages, research collaborations, and clusters of research topics. Explo...
Source: AIDS Reviews - Category: Infectious Diseases Authors: Tags: AIDS Rev Source Type: research
We examined trends in and comorbid conditions associated with hospitalizations and in-hospital mortality in the setting of AKI-D among people with versus without diabetes.Study DesignCross-sectional study.Setting &ParticipantsNationally representative data from the National Inpatient Sample and National Health Interview Survey were used to generate 16 cross-sectional samples of US adults (aged ≥18 years) between 2000 and 2015.ExposureDiabetes, defined using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) diagnosis codes.OutcomeAKI-D, defined using ICD-9-CM diagnos...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Authors: Lal C, Khan A Abstract Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of death in the United States. Due to the substantial public health burden of COPD, there has been a lot of interest in developing new drug therapies, directed at improving the symptomatology and quality of life in COPD patients. Revefenacin is the first once daily nebulized long acting muscarinic antagonist for COPD treatment. It offers an advantage over other nebulized bronchodilators, as once daily administration may improve patient compliance. Revefenacin has a rapid onset of action, is long acting and signific...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Publication date: Available online 13 December 2019Source: BurnsAuthor(s): Clifford C. Sheckter, Christopher Pham, Danielle Rochlin, Zeshaan N. Maan, Yvonne Karanas, Catherine CurtinAbstractIntroductionClinical volume has been associated with rate of complications and mortality for various conditions and procedures. We aim to analyze the relationship between annual hospital burn admission, patient safety indicators (PSI), line infections, and inpatient mortality. We hypothesize that high facility volume will correlate with better outcomes.MethodsAll burn admissions with complete data for total body surface area (TBSA) and ...
Source: Burns - Category: Dermatology Source Type: research
ConclusionThe recognition of pSS underlying an ILD can be challenging in seronegative patients with no or mild sicca symptoms. A complete diagnostic assessment, including minor salivary glands and, in some cases, lung biopsy, should be performed on all patients at risk. A better recognition of the clinical or serological markers of ILD progression in these patients is warranted to drive the physicians to an early diagnosis and an effective treatment.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
n Rieseberg Resolving the origin of endangered taxa is an essential component of conservation. This information can be used to guide efforts of bolstering genetic diversity, and also enables species recovery and future evolutionary studies. Here, we used low-coverage whole genome sequencing to clarify the origin of Helianthus schweinitzii, an endangered tetraploid sunflower that is endemic to the Piedmont Plateau in the eastern United States. We surveyed four accessions representing four populations of H. schweinitzii and 38 accessions of six purported parental species. Using de novo approaches, we assembled 87,004 bp ...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
More News: Bacterial Pneumonia | Chlamydophila | Chlamydophila pneumoniae | Drugs & Pharmacology | Enterococcus | Food and Drug Administration (FDA) | Haemophilus Influenzae (Hib) | Legionnaires' Disease | Pneumonia | Study | USA Health