Acute Kidney Injury Common With Immune Checkpoint Inhibitors Acute Kidney Injury Common With Immune Checkpoint Inhibitors
About one in six cancer patients treated with immune-checkpoint inhibitors develops at least transient acute kidney injury (AKI), a retrospective study found.Reuters Health Information
More than 20 percent of those with family history of cancer had childhood asthma
E-cigarettes may be more harmful to a smoker’s heart than traditional tobacco cigarettes. That’s the finding of new research from Cedars-Sinai Medical Center in Los Angeles, presented today (Nov. 11) at an American Heart Association scientific conference. The Cedars-Sinai team compared the hearts of 10 non-smokers to the hearts of 10 tobacco smokers and 10 e-cigarette smokers. All the people in the study were younger than 40, and all were otherwise healthy. In response to a mild bout of exercise, measures of blood flow increased in the hearts of the non-smokers. Among the tobacco smokers, this increase was blun...
(American College of Allergy, Asthma, and Immunology) New study being presented at the American College of Allergy, Asthma and Immunology (ACAAI) Annual Scientific Meeting in Houston shows an association between a family history of cancer and a childhood asthma diagnosis.
Earlier diagnosis and the tackling of underlying risk factors are urgently needed if the dramatic increase in liver cancer and low cancer-specific treatment rates are to be reversed, say experts.Medscape News UK
Cancer is one of the leading causes of death worldwide, with a high incidence of hypersensitivity reactions (HSR) to first-line chemotherapeutic agents. There is a 9% risk of HSR to taxanes during the first infusion. Two mechanisms could explain the immediate HSR to taxanes: complement activation caused by the emulsifying agents used in its formulation and an IgE-mediated reaction.
Trastuzumab is a humanized mouse IgG1 mAb with selective affinity for the human EGF2 protein, HER-2, approved for the treatment of metastatic breast cancer. Rates of hypersensitivity reaction range from 0.6 to 5%.
Checkpoint inhibitors, as nivolumab, are increasingly relevant in the treatment of several types of cancer. Eosinophilia related to these medications can occur at an estimated frequency of 2.9%. Previous reports suggest eosinophilia is associated to prolonged survival in patients with melanoma receiving nivolumab.
CDX-0159 is a humanized anti-KIT IgG1 monoclonal antibody being evaluated as a modulator of mast cell (MC)-related diseases including chronic idiopathic urticaria. The receptor KIT regulates MC growth, survival, chemotaxis and degranulation, suggesting KIT inhibition as a unique approach to modulate MC activity. CDX-0159 is a re-engineered variant of CDX-0158, a potent KIT inhibitor that decreased MC numbers in several preclinical models and decreased plasma tryptase levels in cancer patients, indicating a reduction in MC numbers/activity.
There is immunologic dysregulation underlying allergic disease and cancer occurrence. Continuing previous work on the relationship between asthma and cancer, the purpose of this study was to examine the trans-generational association of family histories of cancer (FHC) on childhood asthma diagnoses in the National Health Interview Survey (NHIS) from 2012-2016.
A 44-year-old man was evaluated for recurrent angioedema manifested as more than 10 discrete episodes with swelling of the posterior pharynx and uvula, without urticaria, that would subside spontaneously over 24 hours. These episodes were first noted 2 years ago, were worsened by alcohol, and were not responsive to antihistamines. Medical history was significant for hyperestrogenism, that worsened with testosterone treatment for infertility. His primary family history revealed a father and brother with gynecomastia, a mother with endometrial cancer, and a sister with Lynch syndrome.