LncRNA PVT1 aggravates the progression of glioma via downregulating UPF1.

CONCLUSIONS: PVT1 accelerates the proliferative and migratory abilities of glioma via downregulating UPF1. PMID: 31696483 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

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Publication date: Available online 28 March 2020Source: Journal of Clinical NeuroscienceAuthor(s): Wen Wang, Junsheng Li, Fa Lin, Jia Guo, Jizong Zhao
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Abstract Mutations in isocitrate dehydrogenase (IDH) and telomerase reverse transcriptase promoter (TERTp) exert a far-reaching influence on clinicopathologic diagnosis and prognosis of glioma. Traditional approaches, such as Sanger sequencing and ARMS, lack sensitivity due to tumor heterogeneity and low tumor purity of glioma samples. Therefore, we propose a highly sensitive detection method for IDH1 and TERTp mutations based on ddPCR technology, named IDH1-TERT-mutation ddPCR (IT-ddPCR). We determined the IDH1 and TERTp mutations of 80 patients by Sanger sequencing, ARMS, and IT-ddPCR in parallel. We detected th...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
CONCLUSION: Codeletion of 1p/19q with IDH1 mutation in HGG is associated with a significantly favourable PFS. However, larger studies with longer follow up are required to evaluate OS and PFS in all the molecular subgroups. PMID: 32212804 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
Conclusions Preoperative weakness is traditionally accepted as a relative contraindication to IOM and therefore its usefulness is questioned in this context. Our case challenges this assumption. We present the clinical course, review the cranial and spinal literature including the reliability of IOM in cases of preoperative motor deficit, and discuss the need for tailor-made IOM strategies. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Case Report Source Type: research
ConclusionRIPK3 expression levels can be used in combination with IDH mutational status to better subgroup LGG patients regarding overall survival.
Source: Journal of Neuro-Oncology - Category: Cancer & Oncology Source Type: research
AbstractThe molecular biology of human glioma is a complex and fast-growing field in which basic research needs to meet clinical expectations in terms of anti-tumor efficacy. Although much effort is being done in molecular biology research, significant contribution to the quality of life and overall survival still lacks. The vastness of molecular biology literature makes it virtually impossible for clinicians to keep up to date in the field. This paper reviews some practical concepts regarding glioma tumorigenesis from the clinician ’s perspective. Five main aspects are discussed: major intracellular signaling pathwa...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
New J. Chem., 2020, Advance Article DOI: 10.1039/C9NJ05366B, PaperHailing Han, Ying Zhang, Shunzi Jin, Ping Chen, Shi Liu, Zhigang Xie, Xiabin Jing, Zhanfeng Wang The RVG29 –dextran–PTX nanoparticles can cross the BBB, reach the brain glioma, and thus improve PTX efficacy. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
CONCLUSIONS: PVT1 promotes proliferation, invasion, and aerobic glycolysis in glioma cells by regulating miR-140-5p. PMID: 31957841 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
This study investigated the function and mechanism of PVT1 knockdown in the proliferation and malignant transformation of human gliomas. We firstly examined the expression levels of PVT1 and miR-424 in human glioma tissues and cell lines. We also used gene manipulation techniques to explore the effects of PVT1 knockdown on cell viability, migration, invasion, and miR-424. We found that PVT1 knockdown effectively inhibited cell viability, migration and invasion of human glioma cells and increased miR-424 expression. Based on the negative correlation between PVT1 and miR-424, we then confirmed the direct interaction between ...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research
This study aimed to assess the relationship between plasmacytoma variant translocation 1 (PVT1) and enhancer of zeste homolog 2 (EZH2), and their effects on the proliferation and invasion of glioma cells. The expression levels of PVT1 and EZH2 in human glioma tissues and cell lines were measured using qRT-PCR. Then, after siRNA-PVT1 and entire PVT1 sequence vector transfection, we determined the regulation roles of PVT1 on the proliferation, apoptosis, migration and invasion of glioma cells.   We found that the expression levels of both PVT1 and EZH2 were up-regulated in human glioma tissues and cell li...
Source: Bioscience Reports - Category: Biomedical Science Authors: Tags: Biosci Rep Source Type: research
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