Validation of a clinical assessment tool for cicatrising conjunctivitis.

CONCLUSIONS: This study has developed the first validated assessment tool applicable to causes of CC. The tool is concise and discriminates patients with varying disease severity. It measures both disease activity and severity and is suitable for clinical and research applications. PMID: 31693934 [PubMed - as supplied by publisher]
Source: The Ocular Surface - Category: Opthalmology Authors: Tags: Ocul Surf Source Type: research

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To characterize the clinical features of patients with direct immunofluorescence (DIF)-negative mucus membrane pemphigoid (MMP).
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
We report a series of three ectodermal dysplasia patients with an ocular phenotype typically seen in ocular mucous membrane pemphigoid; conjunctival immunohistopathology revealed anti-basement membrane autoantibodies in all of them, and systemic immunosuppression proved to be effective in improving symptoms and helping to stabilize ocular surface disease. PMID: 31268817 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Conditions:   Cicatrizing Conjunctivitis;   Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum;   Sjogren Syndrome;   Mucous Membrane Pemphigoid;   Chronic Graft Versus Host Disease;   Chemical Burn to Eye Intervention:   Procedure: minor salivary gland transplantation Sponsor:   National Taiwan University Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ABSTRACT Rosacea is a chronic, progressive disease of unknown cause affecting the eye and the facial skin. Ocular rosacea is often underdiagnosed if the ophthalmologist does not inspect the patient ’ s face adequately during the ocular examination. Severe ocular complications and blindness can occur if the treatment is delayed because of non-diagnosis of the rosacea. Here, we present a case of ocular rosacea in a 78-year-old Caucasian woman. Based on the ocular lesions, which preceded cutaneous involvement, she was misdiagnosed as having ocular cicatricial pemphigoid initially. This case emphasizes the difficulty in ...
Source: Arquivos Brasileiros de Oftalmologia - Category: Opthalmology Source Type: research
This study explored the validity of the First International Consensus on Mucous Membrane Pemphigoid (MMP) guidance, which recommends that clinically indistinguishable patients, who have direct immunofluorescence (DIF)-negative biopsies, be excluded from a diagnosis of MMP. Misdiagnosis, or delayed diagnosis, of MMP with ocular involvement leads to the inappropriate use of topical therapy, the standard of care for causes of cicatrising conjunctivitis other than MMP, rather than systemic immunomodulatory therapy, resulting in irreversible clinical deterioration in patients with MMP.
Source: Ophthalmology - Category: Opthalmology Authors: Tags: Original article Source Type: research
This study explored the validity of the First International Consensus on Mucous Membrane Pemphigoid (MMP) guidance, which recommends that clinically indistinguishable patients, who have direct immunofluorescence (DIF)-negative biopsies, be excluded from a diagnosis of MMP. Misdiagnosis, or delayed diagnosis, of MMP with ocular involvement leads to the inappropriate use of topical therapy, the standard of care for causes of cicatrising conjunctivitis other than MMP, rather than systemic immunomodulatory therapy, resulting in irreversible clinical deterioration in patients with MMP.
Source: Ophthalmology - Category: Opthalmology Authors: Source Type: research
The purpose of this study was to describe a possible causal relationship between ocular cicatricial pemphigoid (OCP) and ocular surface squamous neoplasia. Two middle-aged female patients with already diagnosed OCP were studied in regard to the subsequent onset of conjunctival squamous neoplasia. Their clinical histories, ocular examinations, clinical photographs, and results of biopsies and any ancillary immunofluorescent laboratory evaluation studies were carefully reviewed. One patient had a preinvasive squamous dysplasia and the other an invasive squamous cell carcinoma, both in the unequivocal setting of OCP with bila...
Source: Ophthalmic Plastic and Reconstructive Surgery - Category: Opthalmology Tags: Case Reports Source Type: research
A review of the literature to describe and evaluate the grading methods for ocular involvement in mucous membrane pemphigoid (OcMMP) was completed. Three online databases: MEDLINE, EMBASE and Scopus, were utilised by using a comibnation of search terms. The abstracts of all articles were then appraised for relevance and duplicates exlcuded. Articles of all languages were included using translated abstracts. OcMMP is characterised by chronic cicatrising conjunctivitis that leads to ocular surface disease such as dry eye, symblephara, corneal ulceration, trichiasis, entropion/ectropion and eventually vision loss.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Clinical Outcomes Source Type: research
Conclusions: Pseudopemphigoid represents a rare manifestation of periocular amyloid. Risks and benefits of surgical procedures in this context need to be carefully weighed to minimize the risk of secondary complications. Topical mitomycin C may be considered as a relatively safe adjunct in managing the cicatricial component of the disease.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
Purpose: Despite the availability of systemic immunosuppressants, cicatricial conjunctivitis (CC) remains a potentially blinding ocular surface disease. We aim to describe the combined use of rituximab (RTX) and intravenous immunoglobulin (IVIg) for severe recalcitrant autoimmune CC. Methods: In this single-center retrospective interventional case series with follow-up between 32 and 65 months, 3 cases with mucous membrane pemphigoid (patients 1–3) and 1 case with linear IgA disease (patient 4) were included. Initial conventional immunosuppressive therapy regimens included systemic steroids, dapsone, and mycophenola...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
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