Expert comment: “A case of missing pathology in a patient with LRRK2 Parkinson's disease”

This case presented by Agin-Liebes and colleagues demonstrates how the clinical phenotype of a patient with LRRK2-related Parkinson's disease (PD) due to p.G2019S mutation can be indistinguishable from idiopathic PD. To date, at least 3 large studies have compared the clinical features of LRRK2 G2019S PD (N  = 97 to 516 subjects) and idiopathic PD [1–3]. These features included age-of-onset, motor features, cognitive impairment, depression, other non-motor features, levodopa response, and dyskinesia.

Source: Parkinsonism and Related Disorders - November 6, 2019 Category: Neurology Authors: Lorraine V. Kalia Tags: Correspondence Source Type: research