The effect of Mullein capsule on uterine leiomyomas volume and the amount of menstrual bleeding: A randomized controlled trial

This study was conducted to evaluate the effect of oral Mullein capsule on asymptomatic uterine leiomyomas volume and the amount of menstrual bleeding. In this two-parallel arm triple-blind, randomized, controlled trial, 50 women were selected among women referred to the clinics affiliated to Tabriz University of Medical Sciences aged 18-50 years old, having at least one asymptomatic myoma greater than 2.5-cm, in Iran over 2017-2018. The participants were randomized into two groups. The first group (n = 25) received 400 mg of Mullein powder capsules and the second group (n = 25) received placebo capsules twice a day for 8 weeks. The mean volume of the largest myoma indicated no statistically significant difference (adjusted mean difference (aMD) = -7.6 ml, 95% CI: -22.0 to 6.6). Within-group analysis of the largest myoma volume showed a significant reduction in the Mullein group (MD = -6.8 ml, 95% CI: -13.0 to -6.3(. There was no significant difference in the first (aMD = 1.3, 95% CI: -24.3 to 27.0) and second (aMD = 7.3, 95% CI: -12.6 to 27 .2) cycles regarding the amount of menstrual bleeding. The results of this study showed that treatment with 800 mg of oral Mullein capsules per day for 2 months did not influence the myoma size, and amount of menstrual bleeding, although there was a significant reduction in the size of myoma in the Mullein group.
Source: Journal of Herbal Medicine - Category: Complementary Medicine Source Type: research