Effect of Yiqihuoxue prescription on myocardial energy metabolism after myocardial infarction via cross talk of liver kinase B1-dependent Notch1 and adenosine 5'-monophosphate-activated protein kinase.

CONCLUSION: YQHX promoted cross talk between the LKB1-dependent Notch1 and AMPK in myocardial tissue after myocardial infarction. Furthermore, it regulated the glucose and lipid metabolism of cardiomyocytes at different time points, thereby ameliorating the cardiac energy metabolism via different mechanisms and protecting the heart. PMID: 31682381 [PubMed]
Source: Journal of Traditional Chinese Medicine - Category: Complementary Medicine Authors: Tags: J Tradit Chin Med Source Type: research

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Authors: Lionetti V, Barile L Abstract Over the last 20 years increasing number of patients with multimorbidity and polypharmacy underwent different types of elective non-cardiac and cardiac surgery. Despite surgery is safer today than in the past, rate of perioperative major adverse cardiovascular events is still attracting significant attention from both clinicians and researchers. The perioperative myocardial infarction (PMI), a permanent damage of the heart, is a major cause of short and long term morbidity and mortality in current surgical populations. Although it is primarily the result of local myocardial is...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Authors: Andò G, Vizzari G, Trio O PMID: 31806584 [PubMed - in process]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
Publication date: Available online 26 November 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Zhenhuan Chen, Lu Chen, Kaitong Chen, Hairuo Lin, Mengjia Shen, Lin Chen, Hailin Zhu, Yingqi Zhu, Qiancheng Wang, Fang Xi, Xiaobo Huang, Yuegang Wang, Wangjun Liao, Jianping Bin, Masanori Asakura, Jie Liu, Masafumi Kitakaze, Yulin LiaoAbstractThe role of the cardiac isoform of the electrogenic sodium-bicarbonate ion cotransporter (NBCe1) in cardiac remodeling is not fully understood. The aim of this study was to assess the effects of NBCe1 overexpression on cardiac remodeling induced by myoc...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
ConclusionsSpontaneous reperfusion prior to pPCI in STEMI was associated with a lower risk of adverse clinical events. These exploratory data from a targeted discovery proteomics platform identifies novel proteins across diverse, yet complementary, pathobiological axes that show promise in providing mechanistic insights into spontaneous reperfusion in STEMI.Condensed abstractSpontaneous reperfusion has been established with improved STEMI outcomes, yet its pathobiology is unclear and appears to involve diverse physiological processes. Using a 91-biomarker high-throughput proteomics platform, we studied 683 STEMI patients i...
Source: American Heart Journal - Category: Cardiology Source Type: research
Authors: Liu T, Xu B, Liu Z PMID: 31797653 [PubMed - as supplied by publisher]
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Authors: Wang Y, Jin BJ, Chen Q, Yan BJ, Liu ZL Abstract OBJECTIVE: Myocardial fibrosis (MF) seriously affects normal cardiac function. Meanwhile, MF at post-myocardial infarction (MI) is the leading cause of cardiac dysfunction in patients with acute myocardial infarction (AMI). Therefore, the aim of this study was to investigate the potential effect of microRNA-29b on MF and cardiac function after MI in rats. MATERIALS AND METHODS: In vivo MI model was constructed by ligation of the left anterior descending coronary artery in Sprague-Dawley rats. Lentivirus overexpressing microRNA-29b was established and tran...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Source: St. Michael's Hospital News and Media - Category: Hospital Management Tags: Hospital News Source Type: news
Publication date: Available online 5 December 2019Source: PeptidesAuthor(s): Amanda A. Greenwell, Jadin J. Chahade, John R. UssherAbstractGlucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted primarily from enteroendocrine K cells in the duodenum and proximal jejunum following nutrient ingestion, primarily acting on islet β-cells to potentiate insulin secretion in a glucose-dependent manner. New discoveries of GIPR biology in adipose tissue, as well as findings that co-agonists for the glucagon-like peptide-1 receptor (GLP-1R) and GIPR induce greater weight loss than that seen with GLP-1R agonis...
Source: Peptides - Category: Biochemistry Source Type: research
In this study, we used data mining techniques to search for subtypes in an unbiased fashion. Using electronic signatures of the disease, we identified a cohort of 13,290 patients with NAFLD from a hospital database. We gathered clinical data from multiple sources and applied unsupervised clustering to identify five subtypes among this cohort. Descriptive statistics and survival analysis showed that the subtypes were clinically distinct and were associated with different rates of death, cirrhosis, hepatocellular carcinoma, chronic kidney disease, cardiovascular disease, and myocardial infarction. Novel disease subtypes iden...
Source: Pacific Symposium on Biocomputing - Category: Bioinformatics Tags: Pac Symp Biocomput Source Type: research
CONCLUSIONS: Both low and high Hgb levels were associated with an increased risk of death from various causes, and some diseases showed different patterns according to sex. PMID: 31795616 [PubMed - in process]
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research
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