Xiyanping injection therapy for children with mild hand foot and mouth disease: a randomized controlled trial.
Xiyanping injection therapy for children with mild hand foot and mouth disease: a randomized controlled trial. J Tradit Chin Med. 2017 Jun;37(3):397-403 Authors: Zhang G, Hou Y, Li Y, He L, Tang L, Yang T, Zou X, Zhu Q, Yan S, Huang B, Zhao J, Huang J Abstract OBJECTIVE: To evaluate the clinical effects of Xiyanping injection intervention in pediatric patients with mild hand foot and mouth disease (HFMD). METHODS: A total of 329 patients were stratified and block-randomized for symptomatic treatment of HFMD and assigned to one of the following groups: Western Medicine (group A, n = 103), Xiyanping injection (group B, n = 109), or Xiyanping injection and symptomatic treatment using Western Medicine (group C, n = 117). During the trial, fever, rash, ulcers of the mouth were observed among participants in each group before and after treatment, and conversion rates from mild to severe HFMD were measured. RESULTS: After 3-7 days' treatment, no significant differences in the conversion rates from mild to severe HFMD were observed among the three groups (P> 0.05). There was a significantly low number of patients with the onset time of antifebrile effect, vanished time of hand and foot rashes and cumulative time for the ulcers in the mouth vanished, among the three groups (P
Hand, foot, and mouth disease (HFMD) is a highly contagious disease that usually affects infants and young children (
In this study, complete genome sequences from 11 CV-A8 strains isolated from HFMD patients in extensive regions from China between 2013 and 2018 were determined, and all sequences from GenBank were retrieved. A phylogenetic analysis based on a total of 34 complete VP1 sequences of CV-A8 revealed five genotypes: A, B, C, D and E. The newly emerging genotype E presented a highly phylogenetic divergence compared with the other genotypes and was composed of the majority of the strains sequenced in this study. Markov chain Monte Carlo (MCMC) analysis revealed that genotype E has been evolving for nearly a century and somehow ar...
Researchers have identified a potential new drug to treat enterovirus 71, a common cause of hand, foot and mouth disease, in a study published Tuesday in the journal Nature Communications.
(Duke University) Duke researchers have identified a potential drug candidate against enterovirus 71, a common cause of hand, foot and mouth disease in infants and young children. The compound of interest is a small molecule that binds to RNA, the virus's genetic material, and changes its 3-D shape in a way that stops the virus from multiplying without harming its human host. It's an antiviral strategy that could be used on other hard-to-treat diseases.
Discussion Oral ulcers are common problems seen by dentists but pediatricians also see them. Usually families have are concerned because they are painful and acute. Ulcers are sometime noticed by the physician and not the family as in the case of herpangina or hand-foot and mouth disease. Chronic or recurrent ulcerations present less commonly and therefore it may be more difficult to determine their etiology. Many of the systemic disease causes of oral ulcers are overall infrequent and/or not common in the pediatric age range. Ulcers can be classified in several ways but acute ulcers are usually painful and last less tha...
Background: Hand, foot and mouth disease (HFMD) continues to challenge Asia with pandemic potential. In Vietnam, there have been two major outbreaks occurring during 2011 –2012 (>200,000 hospitalizations and>200 deaths) and more recently in 2018 (>130,000 hospitalizations and 17 deaths). Given the high burden and the complex epidemic dynamics of HFMD, synthesizing its clinical and epidemiological data remains essential to inform the development of appropriate interventions and design public health measures.
This study aims to investigate age-specific and cumulative incidence rates and risk factors of EV71 infections from 2006 to 2012 in northern Taiwan.
Background: Hand, Foot and Mouth Disease (HFMD), a common childhood illness recognized as endemic in Asia-Pacific countries, poses major public health concerns in this region. Most of HFMD outbreaks have been caused by Enterovirus A, predominantly enterovirus A71 (EV-A71), coxsackievirus A16 (CVA16), CVA10 and CVA6. In Vietnam, CVA16, together with EV-A71 and CVA6, is the most common causes of HFMD. Nevertheless, there has been limited data available regarding CVA16 epidemiology and genetic diversity in Vietnamese population.
Conclusions: The incidence and severity of EV71-related HFMD decreased following implementation of EV71 vaccination. Developing multivalent vaccines and strengthening laboratory-based surveillance could further decline burden of HFMD.
In conclusion, EV-A71 is still the main pathogen causing severe HFMD, although other EV types can also cause severe complications. Potential virulence or phenotype-associated sites were identified in the genomes of CVA6, CVA16, and CVA10.