miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders.

Conclusions: This study provides the first evidence that MI+CIH upregulates miR-214-3p, suppresses cardiac CTRP9 expression, and exacerbates cardiac remodeling, suggesting that CTRP9 may be a novel therapeutic target against pathologic remodeling in MI patients with OSA.
PMID: 31694459 [PubMed - as supplied by publisher]

Source: Circulation Research - November 6, 2019 Category: Cardiology Authors: Du Y, Wang X, Li LY, Hao W, Zhang H, Li Y, Qin Y, Nie S, Christopher T, Lopez B, Wang Y, Lau WB, Wei YX, Ma XL Tags: Circ Res Source Type: research