Effectiveness of repeated influenza vaccination among the elderly population with high annual vaccine uptake rates during the three consecutive A/H3N2 epidemics.

CONCLUSION: During consecutive influenza A/H3N2 epidemics, poor influenza vaccine effectiveness may be more pronounced among the elderly population with a high annual vaccine uptake rate. PMID: 31690467 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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Conclusions: Human challenge studies and systems biology approaches are important tools that should be used in concert to advance our understanding of influenza infection and provide targets for novel therapeutics and immunizations. Introduction Although influenza virus was recognized as an important pathogen over a century ago, influenza continues to cause a significant burden of disease. In the United States alone, it's estimated that in the 2017–2018 season there were 959,000 hospitalizations related to influenza illness, and 79,400 deaths (CDC, 2018). Worldwide, WHO estimates that annual influenza...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
The Objective: To assess the seasonal incidence rate (IR) and mortality rate (MR) because of acute respiratory viral infections (ARVI) and pneumonia (P) in the population of Moscow.The Methods: We used the data on IR and MR of the population because of infectious and parasitic diseases (IPD) (A00-V99 ICD-10), ARVI (J00-02.8-9; J03-J06; J20-J22 ICD-10), P (J12-J16, J18 MCD-10) of the official statistical forms 1, 2, 5, medical death certificates (MDC) of patients from hospitals, microbiology assays nasopharyngeal swabs identifying RNA of influenza virus A(H1N1)09, A(H3N2) and B; bacteriological examinations of sputum.Result...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Conclusions: Often manifested as lower respiratory tract infection, influenza may cause epidemics with increased mortality rate. Influenza should be suspected when interstitial pattern was seen on radiological images. H1N1 cases course worse. Since the prognosis is better in vaccinated patients, seasonal influenza vaccination among the community needs to be elevated. In addition, protective measures like vaccination should be taken in pregnancy to avoid preterm delivery or abortion. PMID: 30246658 [PubMed - in process]
Source: Tuberkuloz ve Toraks - Category: Respiratory Medicine Authors: Tags: Tuberk Toraks Source Type: research
The only thing worse than getting the flu is catching it after you’ve gotten a flu shot. It’s been a terrible year for outbreaks — the worst in almost a decade. Contributing to that is the high failure rate of this year’s vaccine. The current shot is just 25 percent effective against the H3N2 virus, this season’s most-often-identified strain by the Centers for Disease Control and Prevention. The experts say, with enough time and money, they can do a lot better. “There has to be a wholesale change to how we make the flu vaccine,” said Amesh Adalja, senior scholar at Johns Hopkins Ce...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized Bloomberg flu healthytime onetime Source Type: news
Early estimates suggest the flu shot only worked about a third of the time this year. Between Nov. 2 and Feb. 3, total vaccine effectiveness was estimated at 36%, according to a report released Thursday by the CDC. When broken down by strain, however, efficacy varied widely. H3N2, the dominant strain circulating this flu season, is notoriously more virulent and less receptive to vaccination than other types of influenza. True to form, vaccine effectiveness against this strain was low this year — approximately 25%, according to the CDC report. (That’s actually better than experts originally feared, based on tren...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime public health Source Type: news
Early estimates suggest the flu shot only worked about a third of the time this year. Between Nov. 2 and Feb. 3, total vaccine effectiveness was estimated at 36%, according to a report released Thursday by the CDC. When broken down by strain, however, efficacy varied widely. H3N2, the dominant strain circulating this flu season, is notoriously more virulent and less receptive to vaccination than other types of influenza. True to form, vaccine effectiveness against this strain was low this year — approximately 25%, according to the CDC report. (That’s actually better than experts originally feared, based on tren...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime public health Source Type: news
Conclusions: Development of severe complications of influenza has been associated with the lack of immunization, early diagnosis, timely antiviral therapy and late medical aid appealability. The timely inclusion of ECMO to the therapeutic regimen allows to treat severe hypoxemia, which is not corrected by other methods, and this increases the chances of patients’ recovery.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Acute Critical Care Source Type: research
In conclusion, influenza A virus infection was detected rather high with a rate of 20.5% in the study group. The monitoring of influenza virus types and subtypes is required for the evaluation of influenza vaccine strains and circulating influenza viruses and for the identification of subtypes with pandemic potential. Planning for appropriate antiviral therapy using real-time RT-PCR in the early diagnosis of influenza virus infections will significantly contribute to the management of the patient's treatment. Thus, unnecessary drug use will be prevented and controlled with effective treatment of the disease at the time of ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Conclusion In the patients who developed influenza virus-associated pneumonia, those with pH1N1 virus-associated pneumonia frequently developed primary viral pneumonia resulting in bilateral and broad areas of GGOs on imaging, whereas patients with H3N2 virus-associated pneumonia frequently showed consolidation and diffuse bronchial wall thickening on pulmonary imaging. PMID: 27041156 [PubMed - in process]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion Understanding epidemiology of HCoV-NL63 in Taiwan provides an insight for worldwide surveillance of HCoV-NL63 infection.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
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