Regulation of Alzheimer’s disease-associated proteins during the course of epileptogenesis: differential proteomic analysis in a rat model

Publication date: Available online 6 November 2019Source: NeuroscienceAuthor(s): Eva-Lotta von Rüden, Christina Zellinger, Julia Gedon, Andreas Walker, Vera Bierling, Cornelia A. Deeg, Stefanie M. Hauck, Heidrun PotschkaAbstractClinical evidence and pathological studies suggest a bidirectional link between temporal lobe epilepsy and Alzheimer’s disease. Data analysis from omic studies offers an excellent opportunity to identify the overlap in molecular alterations between the two pathologies.We have subjected proteomic data sets from a rat model of epileptogenesis to a bioinformatics analysis focused on proteins functionally linked with Alzheimer’s disease. The data sets have been obtained for hippocampus and parahippocampal cortex samples collected during the course of epileptogenesis.Our study confirmed a relevant dysregulation of proteins linked with Alzheimer pathogenesis.When comparing the two brain areas, a more prominent regulation was evident in parahippocampal cortex samples as compared to the hippocampus. Dysregulated protein groups comprised those affecting mitochondrial function and calcium homeostasis. Differentially expressed mitochondrial proteins included proteins of the mitochondrial complexes I, III, IV, and V as well as of the accessory subunit of complex I.The analysis also revealed a regulation of the microtubule associated protein Tau in parahippocampal cortex tissue during the latency phase. This was further confirmed by immunohistochemistry.Moreov...
Source: Neuroscience - Category: Neuroscience Source Type: research