The Transsulfuration Pathway Makes, the Tumor Takes.

The Transsulfuration Pathway Makes, the Tumor Takes.
Cell Metab. 2019 Nov 05;30(5):845-846
Authors: Weber R, Birsoy K
Abstract
Cells can take up cysteine or synthesize it de novo from methionine, but synthesis alone does not meet the high demands of cancer cells to proliferate. In this issue, Zhu et al. (2019) identify the SAH:SAM ratio, indicative of the cellular methylation state, as limiting for effective cysteine synthesis and the growth of some tumors.
PMID: 31693878 [PubMed - in process]

Source: Cell Metabolism - November 4, 2019 Category: Cytology Authors: Weber R, Birsoy K Tags: Cell Metab Source Type: research