Let ’s make sure everyone in Britain can access the healthcare they need

Doctors of the World is an independent humanitarian organisation and we will not stay quiet when it comes to protecting the right to healthcare and the health of our patients, beyond party politics and easy electoral slogans. For the General Election 2019, we put forward our policy recommendations outlining the key changes the next government needs to make to ensure everyone living in the UK can get the healthcare they need. Our recommendations are grounded in our patients’ experience of accessing NHS services. We include eight questions you can ask candidates to better understand their stance on access to healthcare and a brief containing more information about the status of EU citizens in the UK after Brexit. Share it with your friends and family, ask questions at hustings and on social media. Help ensure everyone in Britain can access the healthcare they need, even if they cannot vote. Let’s make sure everyone in Britain can access the healthcare they need The UK has a proud history of accessible healthcare. The NHS is one of the most inclusive services in the world, founded in 1948 to universally provide comprehensive healthcare, free at the point of delivery. The UK committed to working towards universal health coverage in the 2015 Sustainable Development Goals – meaning the system should be seeking to expand coverage to everyone in the country. Refugees and migrants have long been excluded from healthcare by restrictive policies and laws that undermin...
Source: Doctors of the World News - Category: International Medicine & Public Health Authors: Tags: Uncategorised Source Type: news

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Publication date: Available online 27 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Yunus Akkoc, Devrim GozuacikAbstractAutophagy is a cellular stress response mechanism activation of which leads to degradation of cellular components, including proteins as well as damaged organelles in lysosomes. Defects in autophagy mechanisms were associated with several pathologies (e.g. cancer, neurodegenerative diseases, and rare genetic diseases). Therefore, autophagy regulation is under strict control. Transcriptional and post-translational mechanisms that control autophagy in cells and ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
[Nation] The Nakuru County government has embarked on a mission to seal loopholes that allow for the loss of drugs in public hospitals.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[This Day] Lagos -Nigeria should take advantage of the ban by making the country habitable.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Nation] The Daily Nation's article titled 'How Nairobi Women's Hospital milked patients dry in crazy revenue game' has elicited mixed reactions from the public.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders. Ketamine produces a rapid increase in extracellular glutamate and synaptic formation in the prefrontal cortex, but the initial cellular trigger that initiates this increase and ketamine’s behavioral actions has not been identified. To address this question, we used a combination of viral shRNA and conditional mutation to produce cell-specific knockdown or deletion of a key NMDAR subunit, GluN2B, impli...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Hematological malignancies have long been at the forefront of the development of novel immune-based treatment strategies. The earliest successful efforts originated from the extensive body of work in the field of allogeneic hematopoietic stem cell transplantation. These efforts laid the foundation for the recent exciting era of cancer immunotherapy, which includes immune checkpoint blockade, personal neoantigen vaccines, and adoptive T cell transfer. At the heart of the specificity of these novel strategies is the recognition of target antigens presented by malignant cells to T cells. Here, we review the advances in system...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Immune response to therapeutic enzymes poses a detriment to patient safety and treatment outcome. Enzyme replacement therapy (ERT) is a standard therapeutic option for some types of mucopolysaccharidoses, including Morquio A syndrome caused by N-acetylgalactosamine-6-sulfate sulfatase (GALNS) deficiency. Current protocols tolerize patients using cytotoxic immunosuppressives, which can cause adverse effects. Here we show development of tolerance in Morquio A mice via oral delivery of peptide or GALNS for 10 days prior to ERT. Our results show that using an immunodominant peptide (I10) or the complete GALNS enzyme to orally ...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship between these phenomena remains poorly defined. Here, we showed that hyperexcitability recapitulates TDP43 pathology by upregulating shortened TDP43 (sTDP43) splice isoforms. These truncated isoforms accumulated in the cytoplasm and formed insoluble inclusions that sequestered full-length TDP43 via preserved N-terminal interactions. Consistent with these findings, sTDP43 overexpression was toxic to mammalian neurons, suggesting neurodegeneration...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The human lipidome comprises over tens of thousands of distinct lipid species in addition to total cholesterol and the other conventional lipid traits that are routinely measurable in the peripheral circulation. Of the lipid species considered to exhibit bioactive functions, sphingolipids are a class of molecules that have shown relevance to human disease risk and cardiovascular outcomes in particular. In this issue of the JCI, Poss et al. conducted targeted lipidomics in a case-control study involving over 600 individuals and found a sphingolipid profile that predicted coronary artery disease status. In the context of eme...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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