GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF ‐κB Signalling

ConclusionsOur results suggest that GRK5 regulates cartilage degradation through a catabolic response mediated by NF ‐κB signalling, and is a potential target for OA treatment. Furthermore, amlexanox may be a major compound in relevant drugs.

Source: Arthritis and Rheumatology - November 5, 2019 Category: Rheumatology Authors: Takuya Sueishi, Yukio Akasaki, Norio Goto, Ichiro Kurakazu, Masakazu Toya, Masanari Kuwahara, Taisuke Uchida, Mitsumasa Hayashida, Hidetoshi Tsushima, Hirofumi Bekki, Martin K. Lotz, Yasuharu Nakashima Tags: FULL LENGTH Source Type: research