Dementia test: ‘Velcro’ style test could spot Alzheimer’s years before symptoms develop

DEMENTIA is a syndrome associated with an ongoing decline in brain functioning, with Alzheimer ’s disease being the most common type in the UK. While there is currently no cure, a “velcro” style test has been developed to spot symptoms years before they develop.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news

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Nicotinamide phosphoribosyltransferase‑related signaling pathway in early Alzheimer's disease mouse models. Mol Med Rep. 2019 Oct 30;: Authors: Xing S, Hu Y, Huang X, Shen D, Chen C Abstract Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that is characterized by progressive cognitive dysfunction and which ultimately leads to dementia. Studies have shown that energy dysmetabolism contributes significantly to the pathogenesis of a variety of aging‑associated diseases and degenerative diseases of the nervous system, including AD. One focus of research thus has be...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
DiscussionCMDs, especially when comorbid, are associated with increased dementia risk; however, leisure activities and social integration mitigate this risk.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
(Regenstrief Institute) Regenstrief Institute research scientists Christopher Callahan, M.D., and Alexia Torke, M.D., will play a key role in a major nationwide effort to improve healthcare and quality of life for people with Alzheimer's disease and related dementias. The project, funded by the National Institute on Aging, will create a massive collaborative research incubator to develop trials aimed at evaluating interventions for the disease that affects more than 5 million Americans. Drs. Callahan and Torke will lead the Training Core of the IMPACT Collaboratory.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Despite recent setbacks, disease-modifying treatments (DMTs) for Alzheimer disease (AD) might become available within a few years. These DMTs are likely to be used in the early stages of AD to avoid the progression to manifest dementia, which implies that a large reservoir of prevalent cases would need to be evaluated when DMTs first become available. Primary care providers (PCPs) would play a vital role in managing the patient flow to specialty care. We review the literature on diagnostic tests that could be used by PCPs and estimate the impact of different testing approaches on demand for specialty care. While many tests...
Source: Journal of the American Board of Family Medicine - Category: Primary Care Authors: Tags: Special Communication Source Type: research
AbstractWe aimed to explore the coping strategies utilized by Latino caregivers of people with Alzheimer ’s disease or related dementia (ADRD). We conducted 16 semi-structured interviews with Latinos family caregivers. The interviews explored the caregivers’ experiences utilizing coping strategies. Coping strategies were identified based on a direct content analysis of the interviews. Participants were 50 to 75 years old, majority female, and from Mexico. The most common coping strategies adopted were: rationalization, social interactions, physical activity, and leisure activities. Other strategies used in...
Source: Journal of Cross-Cultural Gerontology - Category: Geriatrics Source Type: research
Publication date: Available online 6 November 2019Source: The Lancet NeurologyAuthor(s): Jie Ding, Kendra L Davis-Plourde, Sanaz Sedaghat, Phillip J Tully, Wanmei Wang, Caroline Phillips, Matthew P Pase, Jayandra J Himali, B Gwen Windham, Michael Griswold, Rebecca Gottesman, Thomas H Mosley, Lon White, Vilmundur Guðnason, Stéphanie Debette, Alexa S Beiser, Sudha Seshadri, M Arfan Ikram, Osorio Meirelles, Christophe TzourioSummaryBackgroundDementia is a major health concern for which prevention and treatment strategies remain elusive. Lowering high blood pressure with specific antihypertensive medications (AHMs) ...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Since areas that dictate personality rather than memory are the first to suffer, people with the disease usually land on a therapist ’s couch long before finding their way to a neurologist.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Dementia Frontotemporal Dementia Alzheimer ' s Disease Memory Source Type: news
(Alzheimer's Association) To address the growing worldwide public health crisis due to dementia, the prevalence of which is expected to triple worldwide to 152 million by 2050, three leading organizations announced this year's Pilot Awards for Global Brain Health Leaders.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Publication date: Available online 6 November 2019Source: Alzheimer's &DementiaAuthor(s): Martin Tolar, Susan Abushakra, Marwan SabbaghAbstractDevelopment of disease-modifying treatments for Alzheimer's disease (AD) has been challenging, with no drugs approved to date. The failures of several amyloid-targeted programs have led many to dismiss the amyloid beta (Aβ) hypothesis of AD. An antiamyloid antibody aducanumab recently showed modest but significant efficacy in a phase 3 trial, providing important validation of amyloid as a therapeutic target. However, the inconsistent results observed with aducanumab may be ...
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Abstract BACKGROUND: We investigated the structural changes associated with Alzheimer's disease, dementia with Lewy bodies and Parkinson disease dementia by means of cortical thickness analysis. METHODS: Two hundred and forty-five participants: 76 Alzheimer's disease, 65 dementia with Lewy bodies, 29 Parkinson disease dementia and 76 cognitively normal controls underwent 3-T T1-weighted magnetic resonance imaging and clinical and cognitive assessments. We implemented FreeSurfer to obtain cortical thickness estimates to contrast patterns of cortical thinning across groups and their clinical correlates. RE...
Source: The Australian and New Zealand Journal of Psychiatry - Category: Psychiatry Authors: Tags: Aust N Z J Psychiatry Source Type: research
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